Noxafil Dosage

Generic name: posaconazole (oral/injection)
Drug class: Azole antifungals

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  DR TAB: 100 mg; SUSP: 40 mg per mL; INJ: various

Invasive fungal infection prophylaxis, immunocompromised pts

[delayed-release form]

Dose: 300 mg DR PO qd; Start: 300 mg DR PO bid x1 day; Info: 1st-line tx for invasive aspergillosis prophylaxis; duration based on immunosuppression recovery; do not cut/crush/chew DR tab

[suspension form]

Dose: 200 mg susp PO tid; Info: duration based on immunosuppression recovery; give w/ full meal, liquid nutrient supplement, or acidic carbonated beverage

[IV form]

Dose: 300 mg IV q24h; Start: 300 mg IV q12h x1 day; Info: duration based on immunosuppression recovery

Candidiasis, oropharyngeal

[suspension form]

Dose: 100 mg susp PO qd x13 days; Start: 100 mg susp PO bid x1 day; Info: give w/ full meal, liquid nutrient supplement, or acidic carbonated beverage

Candidiasis, refractory oropharyngeal

[suspension form]

Dose: 400 mg susp PO bid x3 days, then 400 mg susp PO qd for up to 28 days; Info: for itraconazole- or fluconazole-refractory dz; duration based on underlying dz severity, tx response; give w/ full meal, liquid nutrient supplement, or acidic carbonated beverage

Aspergillosis, invasive

[delayed-release form]

Dose: 300 mg DR PO qd for at least 6-12wk; Start: 300 mg DR PO bid x1 day; Info: do not cut/crush/chew DR tab

[IV form]

Dose: 300 mg IV q24h for at least 6-12wk; Start: 300 mg IV q12h x1 day

[*suspension form]

Dose: 200 mg susp PO tid for at least 6-12wk; Info: give w/ full meal, liquid nutrient supplement, or acidic carbonated beverage

Candidiasis, esophageal

[delayed-release form]

Dose: 300 mg DR PO qd; Info: for fluconazole-refractory dz; do not cut/crush/chew DR tab

[suspension form]

Dose: 400 mg susp PO bid; Info: for fluconazole-refractory dz; give w/ full meal, liquid nutrient supplement, or acidic carbonated beverage

Renal dosing

[PO route]

renal impairment: no adjustment; Info: monitor for breakthrough invasive fungal infection if eGFR <20

HD/PD: not defined

[IV route]

eGFR <50: avoid use; Info: PO route preferred due to accumulation of toxic IV vehicle

HD/PD: not defined

Hepatic dosing

[no adjustment]