Niraparib Dosage
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: CAP: 100 mg
Ovarian CA, maintenance tx
- [first-line tx, <77 kg or Plt <150,000]
- Dose: 200 mg PO qd; Start: w/in 12wk of last platinum-based tx; Info: for platinum-sensitive advanced epithelial ovarian, fallopian tube, or primary peritoneal CA; do not open cap
- [first-line tx, >77 kg and Plt >150,000]
- Dose: 300 mg PO qd; Start: w/in 12wk of last platinum-based tx; Info: for platinum-sensitive advanced epithelial ovarian, fallopian tube, or primary peritoneal CA; do not open cap
- [recurrent dz]
- Dose: 300 mg PO qd; Start: w/in 8wk of last platinum-based tx; Info: for platinum-sensitive epithelial ovarian, fallopian tube, or primary peritoneal CA; do not open cap
Homologous recombination deficiency-positive ovarian CA, advanced
- [300 mg PO qd]
- Info: for pts w/ ovarian, fallopian tube, or primary peritoneal CA who have received at least 3 prior tx w/ genomic instability score (GIS) 42 or greater whose dz progressed >6mo after response to last platinum-based tx or w/ confirmed or suspected BRCA mutation; do not open cap
Renal dosing
- CrCl >30: no adjustment; CrCl <30: not defined
- HD/PD: not defined
Hepatic dosing
- bilirubin <1.5x ULN and any AST: no adjustment; bilirubin 1.5-3x ULN and any AST: start 200 mg qd; bilirubin >3x ULN and any AST: not defined
SRC: NLM .