Neupogen Dosage

Generic name: filgrastim
Brand names: Neupogen, Neupogen SingleJect
Drug class: Colony stimulating factors

Medically reviewed by  A Ras MD.


Recommended Adult Dosing

Dosage forms:  INJ (SingleJect pre-filled syringe): 300 mcg per 0.5 mL, 480 mcg per 0.8 mL; INJ (vial): 300 mcg per mL

Neutropenia, post-chemo

[5 mcg/kg/dose SC/IV qd]
Start: >24h after chemo, may incr. dose by 5 mcg/kg/dose per chemo cycle; Info: for pts w/ non-myeloid malignancies or pts w/ AML receiving induction or consolidation chemo; SC route preferred; cont. until ANC >10,000 or for up to 2wk; do not give w/in 24h before chemo

Neutropenia, post-BMT

[10 mcg/kg/dose IV qd]
Start: >24h after chemo, >24h after BMT; Info: decr. dose by 50% if ANC >1000 x3 consecutive days, then D/C if ANC >1000 x3 more consecutive days; incr. dose back to 10 mcg/kg/day if ANC <1000 during 50% dose reduction; restart 5 mcg/kg/day if ANC <1000 after tx D/C

Peripheral blood progenitor cell mobilization

[10 mcg/kg/dose SC qd]
Start: 4 days before 1st leukapheresis, cont. through last leukapheresis; Info: D/C if WBC >100,000

Neutropenia, severe chronic

Start: 6 mcg/kg/dose SC bid; Info: individualize dose based on ANC and clinical course
[idiopathic or cyclic]
Start: 5 mcg/kg/dose SC qd; Info: individualize dose based on ANC and clinical course

Hematopoietic syndrome of acute radiation syndrome

[10 mcg/kg/dose SC qd]
Start: ASAP after suspected or confirmed exposure to radiation doses >2 Gy; Info: cont. until ANC >1000 x3 consecutive CBCs or ANC >10,000 after radiation-induced nadir

Neutropenia, AIDS-assoc.

[1-10 mcg/kg/dose SC qd]
Info: refer to literature for dosing protocols

Renal dosing

[see below]
renal impairment: no adjustment
HD/PD: not defined

Hepatic dosing

[no adjustment]