Neulasta Dosage

Generic name: pegfilgrastim
Brand names: Neulasta, Neulasta Onpro Kit
Drug class: Colony stimulating factors

Medically reviewed by  A Ras MD.

 

Recommended Adult Dosing

Dosage forms:  INJ (pre-filled syringe): 6 mg per 0.6 mL; INJ (Onpro on-body injector): 6 mg

Neutropenia, post-chemo

[6 mg SC x1]
Start: >24h after chemo; Info: for pts w/ non-myeloid malignancies; do not give w/in 14 days before chemo

Hematopoietic subsyndrome of acute radiation syndrome

[6 mg SC qwk x2 doses]
Start: ASAP after suspected or confirmed exposure to radiation doses >2 Gy; Info: do not use on-body injector

Renal dosing

[see below]
renal impairment: no adjustment
HD/PD: not defined

Hepatic dosing

[not defined]

Recommended Peds Dosing

Dosage forms:  INJ (pre-filled syringe): 6 mg per 0.6 mL; INJ (Onpro on-body injector): 6 mg

Neutropenia, post-chemo

[<10 kg]
Dose: 0.1 mg/kg/dose SC x1; Start: >24h after chemo; Info: for pts w/ non-myeloid malignancies; do not give w/in 14 days before chemo
[10-20 kg]
Dose: 1.5 mg SC x1; Start: >24h after chemo; Info: for pts w/ non-myeloid malignancies; do not give w/in 14 days before chemo
[21-30 kg]
Dose: 2.5 mg SC x1; Start: >24h after chemo; Info: for pts w/ non-myeloid malignancies; do not give w/in 14 days before chemo
[31-44 kg]
Dose: 4 mg SC x1; Start: >24h after chemo; Info: for pts w/ non-myeloid malignancies; do not give w/in 14 days before chemo
[>45 kg]
Dose: 6 mg SC x1; Start: >24h after chemo; Info: for pts w/ non-myeloid malignancies; do not give w/in 14 days before chemo

Hematopoietic subsyndrome of acute radiation syndrome

[<10 kg]
Dose: 0.1 mg/kg/dose SC qwk x2 doses; Start: ASAP after suspected or confirmed exposure to radiation doses >2 Gy; Info: do not use on-body injector
[10-20 kg]
Dose: 1.5 mg SC qwk x2 doses; Start: ASAP after suspected or confirmed exposure to radiation doses >2 Gy; Info: do not use on-body injector
[21-30 kg]
Dose: 2.5 mg SC qwk x2 doses; Start: ASAP after suspected or confirmed exposure to radiation doses >2 Gy; Info: do not use on-body injector
[31-44 kg]
Dose: 4 mg SC qwk x2 doses; Start: ASAP after suspected or confirmed exposure to radiation doses >2 Gy; Info: do not use on-body injector
[>45 kg]
Dose: 6 mg SC qwk x2 doses; Start: ASAP after suspected or confirmed exposure to radiation doses >2 Gy; Info: do not use on-body injector

Renal dosing

renal impairment: no adjustment
HD/PD: not defined

Hepatic dosing

[not defined]

 

SRC: NLM .