Nerlynx Dosage

Generic name: neratinib
Drug classes: EGFR inhibitors, HER2 inhibitors

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  TAB: 40 mg

HER2-overexpressing breast CA

[extended adjuvant tx, early stage dz]

Dose: 240 mg PO qd for up to 1y; Alt: 120 mg PO qd x7 days, then 160 mg PO qd x7 days, then 240 mg PO qd for up to 1y total as dose escalation regimen; Info: start after adjuvant trastuzumab-based tx; give w/ food; do not cut/crush/chew tab; give antidiarrheal prophylaxis for at least 1st 8wk of tx if no dose escalation at tx start (see pkg insert for dosing)

[recurrent, metastatic dz]

Dose: 240 mg PO qd; Alt: 120 mg PO qd x7 days, then 160 mg PO qd x7 days, then 240 mg PO qd as dose escalation regimen; Info: for pts who have received 2 or more anti-HER2 based regimens; use w/ capecitabine; give w/ food; do not cut/crush/chew tab; give antidiarrheal prophylaxis for at least 1st 8wk of tx if no dose escalation at tx start (see pkg insert for dosing)

Renal dosing

renal impairment: no adjustment

HD/PD: not defined

Hepatic dosing

[adjust dose amount]

Child-Pugh Class C: start 80 mg qd

SRC: NLM .