Mirapex Dosage

Generic name: pramipexole
Brand names: Mirapex, Mirapex ER
Drug class: Dopaminergic antiparkinsonism agents

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  TAB: 0.125 mg, 0.25 mg, 0.5 mg, 0.75 mg, 1 mg, 1.5 mg

Parkinson dz

[0.5-1.5 mg PO tid]

Start: 0.125 mg PO tid x7 days, then 0.25 mg PO tid x7 days, then may incr. by 0.75 mg/day q7 days; Max: 4.5 mg/day; Info: taper dose by 0.75 mg/day to 0.25 mg PO tid, then taper dose by 0.375 mg/day to D/C

Restless legs syndrome, mod-severe primary

[0.125-0.5 mg PO qpm]

Start: 0.125 mg PO qpm x4-7 days, then may incr. to 0.25 mg PO qpm x4-7 days, then may incr. to 0.5 mg PO qpm; Max: 0.5 mg/day; Info: give 2-3h before bedtime; taper dose gradually to D/C

Sleep-related eating disorder

[0.125-1.5 mg PO qhs]

Start: 0.125 mg PO qhs, then may titrate slowly; Info: taper dose gradually to D/C

Rapid eye movement sleep behavior disorder

[0.125-1.5 mg PO qhs]

Start: 0.125 mg PO qhs, then may titrate slowly; Info: taper dose gradually to D/C

Renal dosing

[parkinsonism]

CrCl 30-50: start 0.125 mg bid, max 0.75 mg tid; CrCl 15-30: start 0.125 mg qd, max 1.5 mg qd; CrCl <15: not defined

HD/PD: not defined

[all other indications]

CrCl 20-60: start 0.125 mg qpm x14 days, then may incr. to 0.25 mg qpm x14 days, then may incr. to 0.5 mg qpm; CrCl <20: not defined

HD/PD: not defined

Hepatic dosing

[no adjustment]

SRC: NLM .