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Mirabegron Dosage

Generic name: mirabegron
Brand names: Myrbetriq, Myrbetriq Granules
Dosage forms: oral suspension, extended release (8 mg/mL); oral tablet, extended release (25 mg; 50 mg)
Drug class: Urinary antispasmodicsMedically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  ER TAB: 25 mg, 50 mg

Overactive bladder

[monotherapy]
Dose: 25-50 mg PO qd; Start: 25 mg PO qd, may incr. to 50 mg PO qd after 4-8wk; Max: 50 mg/day; Info: do not cut/crush/chew tab
[combo tx]
Dose: 25-50 mg PO qd; Start: 25 mg PO qd, may incr. to 50 mg PO qd after 4-8wk; Max: 50 mg/day; Info: give w/ solifenacin; do not cut/crush/chew tab

Renal dosing

[see below]
eGFR 15-29: max 25 mg/day; eGFR <15: avoid use
HD/PD: avoid use

Hepatic dosing

[adjust dose amount]
Child-Pugh Class B: max 25 mg/day; Child-Pugh Class C: avoid use

Recommended Peds Dosing

Dosage forms:  ER TAB: 25 mg, 50 mg; ER SUSP: 8 mg per mL

Detrusor overactivity, neurogenic

[ER suspension form, 3 yo and older, 11-21 kg]
Dose: 24-48 mg PO qd; Start: 24 mg PO qd, may incr. to 48 mg PO qd; Max: 48 mg /day; Info: give w/ food
[ER suspension form, 3 yo and older, 22-34 kg]
Dose: 32-64 mg PO qd; Start 32 mg PO qd, may incr. to 64 mg PO qd; Max: 64 mg/day; Info: give w/ food
[ER suspension form, 3 yo and older, >35 kg]
Dose: 48-80 mg PO qd; Start: 48 mg PO qd, may incr. to 80 mg PO qd after 4-8wk; Max: 80 mg/day; Info: give w/ food
[ER tablet form, 3 yo and older, >35 kg]
Dose: 25-50 mg PO qd; Start: 25 mg PO qd, may incr. to 50 mg PO qd after 4-8wk; Max: 50 mg/day; Info: give w/ food; do not cut/crush/chew tab

Renal dosing

[ER suspension form, 3 yo and older, 11-21 kg]
eGFR 15-29: max 24 mg/day; eGFR <15: avoid use
HD/PD: avoid use
[ER suspension form, 3 yo and older, 22-34 kg]
eGFR 15-29: max 32 mg/day; eGFR <15: avoid use
HD/PD: avoid use
[ER suspension form, 3 yo and older, >35 kg]
eGFR 15-29: max 48 mg/day; eGFR <15: avoid use
HD/PD: avoid use
[ER tablet form, 3 yo and older, >35 kg]
eGFR 15-29: max 25 mg/day; eGFR <15: avoid use
HD/PD: avoid use

Hepatic dosing

[ER suspension form, 3 yo and older, 11-21 kg]
Child-Pugh Class B: max 24 mg/day; Child-Pugh Class C: avoid use
[ER suspension form, 3 yo and older, 22-34 kg]
Child-Pugh Class B: max 32 mg/day; Child-Pugh Class C: avoid use
[ER suspension form, 3 yo and older, >35 kg]
Child-Pugh Class B: max 48 mg/day; Child-Pugh Class C: avoid use
[ER tablet form, 3 yo and older, >35 kg]
Child-Pugh Class B: max 25 mg/day; Child-Pugh Class C: avoid use
SRC: NLM .

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