Metopirone Dosage

Generic name: Metyrapone
Drug classes: Adrenal corticosteroid inhibitors, In vivo diagnostic biologicals

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  CAP: 250 mg

Restricted Distribution in US

[1-732-919-1234]

Info: avail. in US via Direct Success Pharmacy

Hypothalamic pituitary ACTH fxn, diagnosis

[single-dose short test]

Dose: 30 mg/kg/dose PO x1 on day 1; Max: 3 g/dose; Info: give at midnight w/ yogurt or milk; check plasma ACTH or 11-desoxycortisol at 8am next day; give cortisone 50 mg PO x1 on day 2 after levels drawn; see pkg insert for response interpretation and factors that may interfere w/ results

[multiple-dose test]

Dose: 750 mg PO q4h x6 doses; Start: after adequate response to standard ACTH test; Alt: 15 mg/kg/dose PO q4h x6 doses; Info: give w/ milk or snack; check 24h urinary 17-OHCS, urinary 17-KGS; see pkg insert for response interpretation and factors that may interfere w/ results

Cushing syndrome

[0.5-6 g/day PO divided tid-qid]

Start: 0.5-1 g/day PO divided tid-qid; Max: 6 g/day; Info: adjust dose based on clinical response and urinary free cortisol levels or serum cortisol levels

Renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

Hepatic dosing

[not defined]

Recommended Peds Dosing

Dosage forms:  CAP: 250 mg

Restricted Distribution in US

[1-732-919-1234]

Info: avail. in US via Direct Success Pharmacy

Hypothalamic-pituitary ACTH fxn, diagnosis

[single-dose short test]

Dose: 30 mg/kg/dose PO x1 on day 1; Max: 3 g/dose; Info: give at midnight w/ yogurt or milk; check plasma ACTH or 11-desoxycortisol at 8am next day; give cortisone 50 mg PO x1 on day 2 after levels drawn; see pkg insert for response interpretation and factors that may interfere w/ results

[multiple-dose test]

Dose: 15 mg/kg/dose PO q4h x6 doses; Start: after adequate response to standard ACTH test; Info: give minimum 250 mg/dose; give w/ milk or snack; check 24h urinary 17-OHCS, urinary 17-KGS; see pkg insert for response interpretation and factors that may interfere w/ results

Renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

Hepatic dosing

[not defined]

SRC: NLM .