Generic name: methsuximide
Brand name: Celontin
Dosage form: oral capsule (300 mg)
Drug class: Succinimide anticonvulsants
Medically reviewed by A Ras MD.
What is methsuximide?
Methsuximide is a prescription medicine that is used to help control certain kinds of seizures.
Celontin (methsuximide) is an anticonvulsant succinimide, chemically designated as N,2-Dimethyl-2-phenylsuccinimide, with the following structural formula:
Each Celontin capsule contains 300 mg methsuximide, USP. Also contains starch, NF. The capsule contains colloidal silicon dioxide, NF; D&C yellow No. 10; FD&C yellow No. 6; gelatin, NF; and sodium lauryl sulfate, NF.
Before taking methsuximide, tell your doctor:
- If you are allergic to methsuximide; any part of this medicine; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
This medicine may interact with other drugs or health problems.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take methsuximide with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take methsuximide?
- Tell all of your health care providers that you take methsuximide. This includes your doctors, nurses, pharmacists, and dentists.
- Avoid driving and doing other tasks or actions that call for you to be alert until you see how methsuximide affects you.
- Do not stop taking methsuximide all of a sudden without calling your doctor. You may have a greater risk of seizures. If you need to stop methsuximide, you will want to slowly stop it as ordered by your doctor.
- Very bad and sometimes deadly blood cell problems may happen. You will need to have blood tests while you take methsuximide. Talk with your doctor. Tell your doctor right away if you have any signs of infection.
- Have blood work checked as you have been told by the doctor. Talk with the doctor.
- Talk with your doctor before you drink alcohol or use other drugs and natural products that slow your actions.
- This medicine may cause harm to the unborn baby if you take it while you are pregnant. If you are pregnant or you get pregnant while taking methsuximide, call your doctor right away.
- Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
How is methsuximide best taken?
Use methsuximide as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- Take with or without food. Take with food if it causes an upset stomach.
- Do not take capsules that are not full or capsules where the contents have melted.
- Keep taking methsuximide as you have been told by your doctor or other health care provider, even if you feel well.
- Take methsuximide at the same time of day.
- Do not change the dose or stop methsuximide. This could cause seizures. Talk with your doctor.
What do I do if I miss a dose?
- Take a missed dose as soon as you think about it.
- If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
- Do not take 2 doses at the same time or extra doses.
What are the side effects of methsuximide that I need to call my doctor about immediately?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Signs of infection like fever, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color of sputum, pain with passing urine, mouth sores, or wound that will not heal.
- Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
- Signs of lupus like a rash on the cheeks or other body parts, sunburn easy, muscle or joint pain, chest pain or shortness of breath, or swelling in the arms or legs.
- Feeling confused.
- Change in balance.
- Change in eyesight.
- If bright lights bother your eyes.
- Feeling very tired or weak.
- Any unexplained bruising or bleeding.
- Swollen gland.
- If seizures are worse or not the same after starting methsuximide.
- Patients who take methsuximide may be at a greater risk of having thoughts or actions of suicide. The risk may be greater in people who have had these thoughts or actions in the past. Call the doctor right away if signs like low mood (depression), nervousness, restlessness, grouchiness, panic attacks, or changes in mood or actions are new or worse. Call the doctor right away if any thoughts or actions of suicide occur.
- A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.
What are some other side effects of methsuximide?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Feeling sleepy.
- Upset stomach or throwing up.
- Belly pain.
- Not hungry.
- Weight loss.
- Not able to sleep.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.
If overdose is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out methsuximide?
- Store at room temperature.
- Store in a dry place. Do not store in a bathroom.
- Protect from light.
- Protect from heat.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
PRINCIPAL DISPLAY PANEL – 300 MG CAPSULE BOTTLE LABEL
- ALWAYS DISPENSE WITH MEDICATION GUIDE
(Methsuximide Capsules, USP)
- 300 mg
- 100 Capsules
SRC: NLM .