Merrem Dosage
Generic name: meropenem
Drug class: Carbapenems
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: INJ
Skin/skin structure infections, complicated
- [non-pseudomonal infections]
- Dose: 500 mg IV q8h
- [pseudomonal infections]
- Dose: 1 g IV q8h
Intra-abdominal infections, complicated
- [1 g IV q8h]
Febrile neutropenia
- [1 g IV q8h]
Pneumonia
- [hospital-acquired or ventilator-assoc.]
- Dose: 1 g IV q8h x7 days; Info: may extend duration based on clinical response; refer to IDSA guidelines
- [community-acquired]
- Dose: 1 g IV q8h x7 days; Info: for inpatient tx; refer to IDSA guidelines
Anthrax, systemic
- [2 g IV q8h for at least 2wk]
- Info: part of multi-drug regimen; switch to PO abx for post-exposure prophylaxis if inhalational exposure
Renal dosing
- CrCl 26-50: give usual dose q12h; CrCl 10-25: give 50% usual dose q12h; CrCl <10: give 50% usual dose q24h
- HD: 500-1000 mg q24h, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: 500-1000 mg q24h; supplement not defined
Hepatic dosing
- [no adjustment]
Recommended Peds Dosing
- osage forms: INJ
Skin/skin structure infections, complicated
- [non-pseudomonal infections, 3 mo and older, <50 kg]
- Dose: 30 mg/kg/day IV divided q8h; Max: 1.5 g/day
- [non-pseudomonal infections, 3 mo and older, >50 kg]
- Dose: 500 mg IV q8h
- [pseudomonal infections, 3 mo and older, <50 kg]
- Dose: 60 mg/kg/day IV divided q8h; Max: 3 g/day
- [pseudomonal infections, 3 mo and older, >50 kg]
- Dose: 1 g IV q8h
Intra-abdominal infections, complicated
- [<32 wk gestation, <2 wk old]
- Dose: 40 mg/kg/day IV divided q12h
- [<32 wk gestation, 2-11 wk old]
- Dose: 60 mg/kg/day IV divided q8h
- [32 wk gestation and older, <2 wk old]
- Dose: 60 mg/kg/day IV divided q8h
- [32 wk gestation and older, 2-11 wk old]
- Dose: 90 mg/kg/day IV divided q8h
- [3 mo and older, <50 kg]
- Dose: 60 mg/kg/day IV divided q8h; Max: 3 g/day
- [3 mo and older, >50 kg]
- Dose: 1 g IV q8h
Meningitis, bacterial
- [3 mo and older, <50 kg]
- Dose: 120 mg/kg/day IV divided q8h; Max: 6 g/day
- [3 mo and older, >50 kg]
- Dose: 2 g IV q8h
Febrile neutropenia, chemo-induced
- [30-60 mg/kg/day IV divided q8h]
- Max: 2 g/dose; Info: for empiric tx in high-risk pts
Anthrax, systemic
- [neonates >32 wk gestation]
- Dose: 40-90 mg/kg/day IV divided q8h for at least 2wk; Info: dose depends on infection site, gestational and post-natal age; part of multi-drug regimen; switch to PO abx x60 days total if inhalational exposure
- [1 mo and older]
- Dose: 60-120 mg/kg/day IV divided q8h for at least 2wk; Max: 2 g/dose; Info: dose depends on infection site; part of multi-drug regimen; switch to PO abx x60 days total if inhalational exposure
Renal dosing
- CrCl 26-50: give usual divided dose q12h; CrCl 10-25: give 50% usual divided dose q12h; CrCl <10: give 50% usual divided dose q24h
- HD: give 50% usual divided dose q24h, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: give 50% usual divided dose q24h; supplement not defined
Hepatic dosing
- [no adjustment]
SRC: NLM .