Meropenem Dosage

Generic name: meropenem
Brand names: Merrem, Merrem Novaplus
Drug class: Carbapenems

Medically reviewed by  A Ras MD.

 

Recommended Adult Dosing

Dosage forms:  INJ

Skin/skin structure infections, complicated

[non-pseudomonal infections]
Dose: 500 mg IV q8h
[pseudomonal infections]
Dose: 1 g IV q8h

Intra-abdominal infections, complicated

[1 g IV q8h]

Febrile neutropenia

[1 g IV q8h]

Pneumonia

[hospital-acquired or ventilator-assoc.]
Dose: 1 g IV q8h x7 days; Info: may extend duration based on clinical response; refer to IDSA guidelines
[community-acquired]
Dose: 1 g IV q8h x7 days; Info: for inpatient tx; refer to IDSA guidelines

Anthrax, systemic

[2 g IV q8h for at least 2wk]
Info: part of multi-drug regimen; switch to PO abx for post-exposure prophylaxis if inhalational exposure

Renal dosing

CrCl 26-50: give usual dose q12h; CrCl 10-25: give 50% usual dose q12h; CrCl <10: give 50% usual dose q24h
HD: 500-1000 mg q24h, on dialysis days admin. after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: 500-1000 mg q24h; supplement not defined

Hepatic dosing

[no adjustment]

 

SRC: NLM .