Mekinist Dosage

Generic name: trametinib
Drug class: Multikinase inhibitors

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  TAB: 0.5 mg, 2 mg

Melanoma

[adjuvant tx]

Dose: 2 mg PO qd for up to 1y; Info: for pts w/ BRAF V600E or V600K mutation; use w/ dabrafenib; give at least 1h before or 2h after meals

[unresectable or metastatic dz]

Dose: 2 mg PO qd; Info: for pts w/ BRAF V600E or V600K mutation; use as monotherapy or w/ dabrafenib; give at least 1h before or 2h after meals

Non-small cell lung CA, metastatic

[2 mg PO qd]

Info: for pts w/ BRAF V600E mutation; use w/ dabrafenib; give at least 1h before or 2h after meals

Anaplastic thyroid CA, locally advanced or metastatic

[2 mg PO qd]

Info: for pts w/ BRAF V600E mutation; use w/ dabrafenib; give at least 1h before or 2h after meals

BRAF V600E-positive solid tumors, unresectable or metastatic

[2 mg PO qd]

Info: for pts who have progressed after prior tx; not for pts w/ colorectal CA; use w/ dabrafenib; give at least 1h before or 2h after meals

Renal dosing

[see below]

eGFR >15: no adjustment; eGFR <15: not defined

HD/PD: not defined

Hepatic dosing

bilirubin 1.1-1.5x ULN or AST >ULN: no adjustment; bilirubin >1.5x ULN and any AST: not defined

SRC: NLM .