Mayzent Dosage

Generic name: siponimod
Drug class: Selective immunosuppressants

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  TAB: 0.25 mg, 1 mg, 2 mg

Multiple sclerosis, relapsing forms

[CYP2C9 genotype *1/*1 or *1/*2 or *2/*2]

Dose: 2 mg PO qd; Start: 0.25 mg PO qd x2 days, then 0.5 mg PO qd x1 day, then 0.75 mg PO qd x1 day, then 1.25 mg PO qd x1 day, then 2 mg PO qd; Info: for pts w/ clinically isolated syndrome, relapsing-remitting dz, and active secondary progressive dz; restart titration if titration dose missed >24h or if maintenance tx interrupted >4 days; do not cut/crush/chew tab

[CYP2C9 genotype *1/*3 or *2/*3]

Dose: 1 mg PO qd; Start: 0.25 mg PO qd x2 days, then 0.5 mg PO qd x1 day, then 0.75 mg PO qd x1 day, then 1 mg PO qd; Info: for pts w/ clinically isolated syndrome, relapsing-remitting dz, and active secondary progressive dz; restart titration if titration dose missed >24h or if maintenance tx interrupted >4 days; do not cut/crush/chew tab

Renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

Hepatic dosing

hepatic impairment: no adjustment; Info: caution advised if significant liver dz hx, monitor closely

SRC: NLM .