Mavyret Dosage

Generic name: glecaprevir and pibrentasvir
Drug class: Antiviral combinations

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  TAB: 100 mg/40 mg; PELLET: 50 mg/20 mg per pkt

Chronic hepatitis C infection, genotypes 1-6

[tx-naive pts]

Dose: 300 mg/120 mg PO qd x8wk or x12wk; Info: duration depends on cirrhosis status, transplant status; refer to AASLD/IDSA hepatitis C guidelines; give w/ food; do not chew pellets

[tx-experienced pts]

Dose: 300 mg/120 mg PO qd x8wk, x12wk, or x16wk; Info: duration depends on genotype subtype, cirrhosis status, transplant status, prior tx; may give w/ sofosbuvir, ribavirin if glecaprevir/pibrentasvir or sofosbuvir/velpatasvir/voxilaprevir tx failure; refer to AASLD/IDSA hepatitis C guidelines; give w/ food; do not chew pellets

Rdosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

Hepatic dosing

Child-Pugh Class B or C: contraindicated

SRC: NLM .