Lynparza Dosage

Generic name: olaparib
Drug class: PARP inhibitors

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  TAB: 100 mg, 150 mg

Restricted Distribution in US

Dosage Forms Discontinued in US

GBRCA-mutated ovarian CA, advanced

[300 mg PO bid]

Info: for recurrent dz; do not cut/crush/chew tab

Ovarian CA, maintenance tx

[first-line tx, advanced BRCA-mutated dz]

Dose: 300 mg PO bid x2y; Info: for platinum-sensitive epithelial ovarian, fallopian tube, or primary peritoneal CA; do not cut/crush/chew tab; may cont. beyond 2y if dz present and benefit outweighs risk

[first-line tx, advanced homologous recombination deficiency-positive dz]

Dose: 300 mg PO bid x2y; Info: for platinum-sensitive epithelial ovarian, fallopian tube, or primary peritoneal CA; use w/ bevacizumab; do not cut/crush/chew tab; may cont. beyond 2y if dz present and benefit outweighs risk

[recurrent dz]

Dose: 300 mg PO bid; Info: for platinum-sensitive epithelial ovarian, fallopian tube, or primary peritoneal CA; do not cut/crush/chew tab

GBRCA-mutated HER2-negative breast CA

[adjuvant tx, high-risk early dz]

Dose: 300 mg PO bid x1y; Info: do not cut/crush/chew tab

[metastatic, previously treated dz]

Dose: 300 mg PO bid; Info: do not cut/crush/chew tab

Metastatic gBRCA-mutated pancreatic CA, first-line maintenance tx

[300 mg PO bid]

Info: for pts without dz progression for at least 16wk after first-line platinum-based tx; do not cut/crush/chew tab

Homologous recombination repair-mutated prostate CA, metastatic castration-resistant

[300 mg PO bid]

Info: for pts w/ progressive dz following enzalutamide or abiraterone; use w/ GnRH analog in pts w/o bilateral orchiectomy; do not cut/crush/chew tab

Renal dosing

[adjust dose amount]

CrCl 31-50: 200 mg bid; CrCl <30: not defined

HD/PD: not defined

Hepatic dosing

Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined

SRC: NLM .