Lubiprostone Dosage

Generic name: lubiprostone
Brand name: Amitiza
Drug class: Chloride channel activators

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  CAP: 8 mcg, 24 mcg

Chronic idiopathic constipation

[24 mcg PO bid]

Info: give w/ food and water; do not open cap; periodically reassess need for tx

Constipation, opioid-induced

[24 mcg PO bid]

Info: for pts w/ chronic non-cancer pain, incl. pain related to prior cancer or tx; give w/ food and water; do not open cap; periodically reassess need for tx

IBS, constipation-predominant

[8 mcg PO bid]

Info: for female pts; give w/ food and water; do not open cap; periodically reassess need for tx

Renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

Hepatic dosing

[IBS, constipation-predominant]

Child-Pugh Class C: 8 mcg qd; Info: may incr. to 8 mcg bid if tolerated and inadequate response

[all other indications]

Child-Pugh Class B: 16 mcg bid; Child-Pugh Class C: 8 mcg bid; Info: may incr. up to 24 mcg bid if tolerated and inadequate response

SRC: NLM .