Lexiva Dosage

Generic name: fosamprenavir
Drug class: Protease inhibitors

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  TAB: 700 mg; SUSP: 50 mg per mL

HIV infection

[tx-naive]

Dose: 1400 mg PO bid; Alt: 1400 mg PO qd w/ ritonavir 100-200 mg PO qd; 700 mg PO bid w/ ritonavir 100 mg PO bid; Info: not recommended per DHHS guidelines; give susp w/o food in adults pts

[protease inhibitor-experienced]

Dose: 700 mg PO bid; Info: not recommended per DHHS guidelines; give w/ ritonavir 100 mg PO bid; give susp w/o food in adults pts; may give in virologically stable pregnant pts

Renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

Hepatic dosing

[tx-naive]

Child-Pugh score 5-6: 700 mg bid or 700 mg bid w/ ritonavir 100 mg qd; Child-Pugh score 7-9: 700 mg bid or 450 mg bid w/ ritonavir 100 mg qd; Child-Pugh score 10-15: 350 mg bid or 300 mg bid w/ ritonavir 100 mg qd

[protease inhibitor-experienced]

Child-Pugh score 5-6: 700 mg bid w/ ritonavir 100 mg qd; Child-Pugh score 7-9: 450 mg bid w/ ritonavir 100 mg qd; Child-Pugh score 10-15: 300 mg bid w/ ritonavir 100 mg qd

Recommended Peds Dosing

Dosage forms:  TAB: 700 mg; SUSP: 50 mg per mL

HIV infection, protease inhibitor-naive

[>38 wk gestation, 4 wk old and older, <11 kg]

Dose: 45 mg/kg/dose PO bid w/ ritonavir 7 mg/kg/dose PO bid; Info: not recommended per DHHS guidelines; give susp w/ food in peds pts

[>38 wk gestation, 4 wk old and older, 11-14 kg]

Dose: 30 mg/kg/dose PO bid w/ ritonavir 3 mg/kg/dose PO bid; Info: not recommended per DHHS guidelines; may give w/o ritonavir in pts 2 yo and older; give susp w/ food in peds pts

[>38 wk gestation, 4 wk old and older, 15-19 kg]

Dose: 23 mg/kg/dose PO bid w/ ritonavir 3 mg/kg/dose PO bid; Info: not recommended per DHHS guidelines; may give 30 mg/kg/dose PO bid w/o ritonavir in pts >2 yo; give susp w/ food in peds pts

[>38 wk gestation, 4 wk old and older, >20 kg]

Dose: 18 mg/kg/dose up to 700 mg PO bid w/ ritonavir 3 mg/kg/dose up to 100 mg PO bid; Info: not recommended per DHHS guidelines; may give 30 mg/kg/dose up to 1400 mg PO bid w/o ritonavir in pts >2 yo; give susp w/ food in peds pts

HIV infection, protease inhibitor-experienced

[6 mo and older, <11 kg]

Dose: 45 mg/kg/dose PO bid w/ ritonavir 7 mg/kg/dose PO bid; Info: not recommended per DHHS guidelines; give susp w/ food in peds pts

[6 mo and older, 11-14 kg]

Dose: 30 mg/kg/dose PO bid w/ ritonavir 3 mg/kg/dose PO bid; Info: not recommended per DHHS guidelines; give susp w/ food in peds pts

[6 mo and older, 15-19 kg]

Dose: 23 mg/kg/dose PO bid w/ ritonavir 3 mg/kg/dose PO bid; Info: not recommended per DHHS guidelines; give susp w/ food in peds pts

[6 mo and older, >20 kg]

Dose: 18 mg/kg/dose up to 700 mg PO bid w/ ritonavir 3 mg/kg/dose up to 100 mg PO bid; Info: not recommended per DHHS guidelines; give susp w/ food in peds pts

Renal dosing

renal impairment: no adjustment

HD/PD: not defined, consider adult renal dosing for guidance

Hepatic dosing

[not defined]

hepatic impairment: consider adult hepatic dosing for guidance

SRC: NLM .