Letrozole Dosage

Generic name: letrozole
Brand name: Femara
Drug classes: Aromatase inhibitors, Hormones / antineoplastics

Medically reviewed by  A Ras MD.

 

Recommended Adult Dosing

Dosage forms:  TAB: 2.5 mg

Breast CA, postmenopausal

[hormone receptor-positive early dz, adjuvant tx]
Dose: 2.5 mg PO qd; Info: also for extended adjuvant tx after 5y tamoxifen tx
[locally advanced or metastatic dz]
Dose: 2.5 mg PO qd
[advanced, progressive dz]
Dose: 2.5 mg PO qd

Ovulation induction

[2.5-5 mg PO qd x5 days]
Start: day 3 of menstrual cycle

Renal dosing

CrCl >10: no adjustment; CrCl <10: not defined
HD: no adjustment; no supplement; PD: not defined

Hepatic dosing

[adjust dose frequency]
cirrhosis/Child-Pugh Class C: give q48h

Recommended Peds Dosing

Dosage forms:  TAB: 2.5 mg

Precocious puberty

[2 yo and older]
Dose: 2.5 mg PO qd; Info: for female pts w/ McCune-Albright syndrome or male pts w/ testotoxicosis

Renal dosing

[not defined]
renal impairment: consider adult renal dosing for guidance
HD/PD: consider adult renal dosing for guidance

Hepatic dosing

[not defined]
hepatic impairment: consider adult hepatic dosing for guidance

 

 

SRC: NLM .