Letairis Dosage

Generic name: ambrisentan
Drug class: Agents for pulmonary hypertension

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  TAB: 5 mg, 10 mg

Restricted Distribution in US

Pulmonary arterial HTN

[monotherapy]

Dose: 5-10 mg PO qd; Start: 5 mg PO qd, may incr. to 10 mg PO qd after 4wk if tolerated; Max: 10 mg/day; Info: do not cut/crush/chew tab

[combo w/ tadalafil]

Dose: 5-10 mg PO qd; Start: 5 mg PO qd, may incr. to 10 mg PO qd after 4wk if tolerated; Max: 10 mg/day; Info: start w/ tadalafil 20 mg PO qd, max 40 mg/day; do not cut/crush/chew tab

Renal dosing

mild-moderate impairment: no adjustment; severe impairment: not defined

HD/PD: not defined

Hepatic dosing

mild impairment: not defined, caution advised; mod-severe impairment: avoid use

SRC: NLM .