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Kynmobi Dosage

Generic name:  apomorphine hydrochloride
Drug class: Dopaminergic antiparkinsonism agents

Medically reviewed by  A Ras MD.


Recommended Adult Dosing

Dosage forms:  SL STRIP: 10 mg, 15 mg, 20 mg, 25 mg, 30 mg; convenience pack

Acute intermittent hypomobility, Parkinson dz-assoc.

[10-30 mg SL prn]
Start: 10 mg SL x1 test dose during off episode; if 10 mg SL x1 test dose tolerated and effective, give 10 mg SL prn; if inadequate response to 10 mg SL x1 test dose, incr. dose by 5 mg generally w/in 3 days, then may cont. titration in 5 mg increments until adequate response achieved; Max: 1 dose/off episode, 30 mg/dose up to 5 doses/day; Info: consider premed w/ trimethobenzamide starting 3 days prior to 1st dose, then prn for up to 2mo; separate doses by at least 2h; do not cut/chew/swallow strip; taper dose gradually to D/C

Renal dosing

CrCl <30: avoid use
HD/PD: not defined

Hepatic dosing

Child-Pugh Class C: avoid use



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