Kuvan Dosage
Generic name: sapropterin
Drug class: Miscellaneous metabolic agents
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: TAB: 100 mg; PWDR: 100 mg per pkt, 500 mg per pkt
PKU
- [5-20 mg/kg/dose PO qd]
- Start: 10-20 mg/kg/dose PO qd; Max: 20 mg/kg/day; Info: adjust dose based on Phe levels; give w/ food; D/C tx if no decr. in Phe levels at max dose x1mo
Renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
Hepatic dosing
- [not defined]
Recommended Peds Dosing
- Dosage forms: TAB: 100 mg; PWDR: 100 mg per pkt, 500 mg per pkt
PKU
- [1 mo-6 yo]
- Dose: 5-20 mg/kg/dose PO qd; Start: 10 mg/kg/dose PO qd; Max: 20 mg/kg/day; Info: adjust dose based on Phe levels; give w/ food; D/C tx if no decr. in Phe levels at max dose x1mo
- [7 yo and older]
- Dose: 5-20 mg/kg/dose PO qd; Start: 10-20 mg/kg/dose PO qd; Max: 20 mg/kg/day; Info: adjust dose based on Phe levels; give w/ food; D/C tx if no decr. in Phe levels at max dose x1mo
Renal dosing
- [not defined]
- renal impairment: not defined
- HD/PD: not defined
Hepatic dosing
- [not defined]
SRC: NLM .