Krystexxa Dosage

Generic name: pegloticase
Drug class: Antihyperuricemic agents

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  INJ

Gout, refractory chronic

[monotherapy]

Dose: 8 mg IV q2wk; Info: start gout flare prophylaxis w/ NSAID or colchicine >1wk before pegloticase initiation and cont. >6mo; D/C oral urate-lowering meds before and during tx; screen pts of African, Mediterranean, or South Asian ancestry for G6PD deficiency before initiating tx; premed w/ antihistamines, corticosteroids; D/C if serum uric acid levels incr. to >6 mg/dL, esp. when 2 consecutive levels >6 mg/dL

[combo w/ methotrexate]

Dose: 8 mg IV q2wk; Info: start weekly methotrexate w/ folate supplementation at least 4wk before and cont. during tx; start gout flare prophylaxis w/ NSAID or colchicine >1wk before pegloticase initiation and cont. >6mo; D/C oral urate-lowering meds before and during tx; screen pts of African, Mediterranean, or South Asian ancestry for G6PD deficiency before initiating tx; premed w/ antihistamines, corticosteroids; D/C if serum uric acid levels incr. to >6 mg/dL, esp. when 2 consecutive levels >6 mg/dL

Renal dosing

renal impairment: no adjustment

HD/PD: not defined

Hepatic dosing

[not defined]

SRC: NLM .