Koselugo Dosage

Generic name: selumetinib
Drug class: Multikinase inhibitors

Medically reviewed by  A Ras MD.

Recommended Peds Dosing

Dosage forms:  CAP: 10 mg, 25 mg

Neurofibromatosis, type 1

[2 yo and older, BSA 0.55-0.69 m^2]

Dose: 25 mg/m^2/dose PO bid (round to 20 mg PO qam, 10 mg PO qpm); Info: for pts w/ symptomatic, inoperable plexiform neurofibromas; give on empty stomach, 1h before or 2h after food; do not open cap

[2 yo and older, BSA 0.70-0.89 m^2]

Dose: 25 mg/m^2/dose PO bid (round to 20 mg PO bid); Info: for pts w/ symptomatic, inoperable plexiform neurofibromas; give on empty stomach, 1h before or 2h after food; do not open cap

[2 yo and older, BSA 0.90-1.09 m^2]

Dose: 25 mg/m^2/dose PO bid (round to 25 mg PO bid); Info: for pts w/ symptomatic, inoperable plexiform neurofibromas; give on empty stomach, 1h before or 2h after food; do not open cap

[2 yo and older, BSA 1.10-1.29 m^2]

Dose: 25 mg/m^2/dose PO bid (round to 30 mg PO bid); Info: for pts w/ symptomatic, inoperable plexiform neurofibromas; give on empty stomach, 1h before or 2h after food; do not open cap

[2 yo and older, BSA 1.30-1.49 m^2]

Dose: 25 mg/m^2/dose PO bid (round to 35 mg PO bid); Info: for pts w/ symptomatic, inoperable plexiform neurofibromas; give on empty stomach, 1h before or 2h after food; do not open cap

[2 yo and older, BSA 1.50-1.69 m^2]

Dose: 25 mg/m^2/dose PO bid (round to 40 mg PO bid); Info: for pts w/ symptomatic, inoperable plexiform neurofibromas; give on empty stomach, 1h before or 2h after food; do not open cap

[2 yo and older, BSA 1.70-1.89 m^2]

Dose: 25 mg/m^2/dose PO bid (round to 45 mg PO bid); Info: for pts w/ symptomatic, inoperable plexiform neurofibromas; give on empty stomach, 1h before or 2h after food; do not open cap

[2 yo and older, BSA >1.89 m^2]

Dose: 25 mg/m^2/dose PO bid (round to 50 mg PO bid); Info: for pts w/ symptomatic, inoperable plexiform neurofibromas; give on empty stomach, 1h before or 2h after food; do not open cap

Renal dosing

[no adjustment]

renal impairment: no adjustment

HD/PD: no adjustment; no supplement

Hepatic dosing

[BSA 0.55-0.69 m^2]

Child-Pugh Class B: 20 mg/m^2/dose bid (round to 10 mg bid); Child-Pugh Class C: not defined

[BSA 0.70-0.89 m^2]

Child-Pugh Class B: 20 mg/m^2/dose bid (round to 20 mg qam, 10 mg qpm); Child-Pugh Class C: not defined

[BSA 0.90-1.09 m^2]

Child-Pugh Class B: 20 mg/m^2/dose bid (round to 20 mg bid); Child-Pugh Class C: not defined

[BSA 1.10-1.29 m^2]

Child-Pugh Class B: 20 mg/m^2/dose bid (round to 25 mg bid); Child-Pugh Class C: not defined

[BSA 1.30-1.49 m^2]

Child-Pugh Class B: 20 mg/m^2/dose bid (round to 30 mg qam, 25 mg qpm); Child-Pugh Class C: not defined

[BSA 1.50-1.69 m^2]

Child-Pugh Class B: 20 mg/m^2/dose bid (round to 35 mg qam, 30 mg qpm); Child-Pugh Class C: not defined

[BSA 1.70-1.89 m^2]

Child-Pugh Class B: 20 mg/m^2/dose bid (round to 35 mg bid); Child-Pugh Class C: not defined

[BSA >1.89 m^2]

Child-Pugh Class B: 20 mg/m^2/dose bid (round to 40 mg bid); Child-Pugh Class C: not defined

SRC: NLM .