Kombiglyze XR Dosage

Generic name: metformin and saxagliptin
Drug class: Antidiabetic combinations

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  TAB: 2.5 mg IR/1000 mg ER, 5 mg IR/500 mg ER, 5 mg IR/1000 mg ER

Diabetes mellitus, type 2

[conversion from saxagliptin plus metformin]

Dose: 1-2 tabs PO qd; Start: equivalent dose of each component in current regimen; Max: 5 mg/2000 mg/day; Info: give w/ evening meal; do not cut/crush/chew tab; hold tx for surgery if restricting food/fluid; D/C for iodinated contrast study if eGFR 30-60, hepatic dz hx, alcoholism hx, heart failure hx, or receiving contrast intra-arterially; restart after 48h if stable renal fxn

[conversion from saxagliptin]

Dose: 1-2 tabs PO qd; Start: if on saxagliptin 5 mg/day, start 5 mg/500 mg PO qd; if on saxagliptin 2.5 mg/day, start individual component products; Max: 5 mg/2000 mg/day; Info: give w/ evening meal; do not cut/crush/chew tab; hold tx for surgery if restricting food/fluid; D/C for iodinated contrast study if eGFR 30-60, hepatic dz hx, alcoholism hx, heart failure hx, or receiving contrast intra-arterially; restart after 48h if stable renal fxn

[conversion from metformin]

Dose: 1-2 tabs PO qd; Start: saxagliptin 2.5-5 mg PO qd w/ current total daily metformin dose PO qd; Max: 5 mg/2000 mg/day; Info: give w/ evening meal; do not cut/crush/chew tab; hold tx for surgery if restricting food/fluid; D/C for iodinated contrast study if eGFR 30-60, hepatic dz hx, alcoholism hx, heart failure hx, or receiving contrast intra-arterially; restart after 48h if stable renal fxn

Renal dosing

eGFR 30-44: avoid tx initiation; eGFR <30: contraindicated; Info: weigh risk/benefit, max saxagliptin dose 2.5 mg/day if eGFR 30-44 during tx

HD/PD: avoid use

Hepatic dosing

hepatic impairment: avoid use

SRC: NLM .