Kisqali Dosage

Generic name: ribociclib
Drug class: CDK 4/6 inhibitors

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  TAB: 200 mg

Hormone receptor-positive HER2-negative breast CA, advanced or metastatic

[initial tx, combo w/ aromatase inhibitor]

Dose: 600 mg PO qam on days 1-21 of 28-day cycle; Info: give w/ LHRH agonist if used in pre/perimenopausal women or men

[initial tx, combo w/ fulvestrant]

Dose: 600 mg PO qam on days 1-21 of 28-day cycle; Info: for postmenopausal women or men; give w/ LHRH agonist in men

[progressive dz, combo w/ fulvestrant]

Dose: 600 mg PO qam on days 1-21 of 28-day cycle; Info: for postmenopausal women or men; give w/ LHRH agonist in men

Renal dosing

eGFR 15-30: start 200 mg qam; eGFR <15: not defined

HD/PD: not defined

Hepatic dosing

[adjust dose amount]

Child-Pugh Class B or C: start 400 mg qam

SRC: NLM .