Kazano Dosage

Generic name: alogliptin and metformin
Drug class: Antidiabetic combinations

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  TAB: 12.5 mg/500 mg, 12.5 mg/1000 mg

Diabetes mellitus, type 2

[conversion from alogliptin plus metformin]

Dose: 1 tab PO bid; Start: equivalent dose of each component in current regimen; Max: 25 mg/2000 mg/day; Info: give w/ meals; do not cut/crush/chew tab; hold tx for surgery if restricting food/fluid; D/C for iodinated contrast study if eGFR 30-60, hepatic dz hx, alcoholism hx, heart failure hx, or receiving contrast intra-arterially; restart after 48h if stable renal fxn

[conversion from alogliptin]

Dose: 1 tab PO bid; Start: 12.5 mg/500 mg PO bid; Max: 25 mg/2000 mg/day; Info: give w/ meals; do not cut/crush/chew tab; hold tx for surgery if restricting food/fluid; D/C for iodinated contrast study if eGFR 30-60, hepatic dz hx, alcoholism hx, heart failure hx, or receiving contrast intra-arterially; restart after 48h if stable renal fxn

[conversion from metformin]

Dose: 1 tab PO bid; Start: alogliptin 12.5 mg PO bid w/ current metformin dose PO bid; Max: 25 mg/2000 mg/day; Info: give w/ meals; do not cut/crush/chew tab; hold tx for surgery if restricting food/fluid; D/C for iodinated contrast study if eGFR 30-60, hepatic dz hx, alcoholism hx, heart failure hx, or receiving contrast intra-arterially; restart after 48h if stable renal fxn

Renal dosing

eGFR 30-60: avoid use; dose adjustment not possible w/ fixed-dose combo; eGFR <30: contraindicated

HD/PD: avoid use

Hepatic dosing

hepatic impairment: avoid use

SRC: NLM .