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Kanuma Dosage

Generic name: sebelipase alfa
Drug class: Lysosomal enzymes

Medically reviewed by  A Ras MD.

 

Recommended Adult Dosing

Dosage forms:  INJ

Restricted Distribution in US

Lysosomal acid lipase deficiency

[1-3 mg/kg/dose IV q2wk]
Start: 1 mg/kg/dose IV q2wk, then may incr. to 3 mg/kg/dose IV q2wk; Info: consider premed w/ antipyretic, antihistamine if hypersensitivity rxn

Renal dosing

[not defined]
renal impairment: not defined
HD/PD: not defined

Hepatic dosing

[not defined]

Recommended Peds Dosing

Dosage forms:  INJ

Restricted Distribution in US

[1-888-765-4747 or www.kanuma.com for more info]

Lysosomal acid lipase deficiency, rapidly progressive

[1 mo and older]
Dose: 1-5 mg/kg/dose IV qwk; Start: 1 mg/kg/dose IV qwk, then may incr. to 3 mg/kg/dose IV qwk, then may incr. to 5 mg/kg/dose IV qwk; Info: for pts w/ dz presenting w/in 6mo of birth; consider premed w/ antipyretic, antihistamine if hypersensitivity rxn

Lysosomal acid lipase deficiency, non-rapidly progressive

[1 mo and older]
Dose: 1-3 mg/kg/dose IV q2wk; Start: 1 mg/kg/dose IV q2wk, then may incr. to 3 mg/kg/dose IV q2wk; Info: consider premed w/ antipyretic, antihistamine if hypersensitivity rxn

Renal dosing

[not defined]
renal impairment: not defined
HD/PD: not defined

Hepatic dosing

[not defined]

SRC: NLM .

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