Kalydeco Dosage

Generic name: ivacaftor
Drug class: CFTR potentiators

Medically reviewed by  A Ras MD.

 

Recommended Adult Dosing

Dosage forms:  TAB: 150 mg

Cystic fibrosis

[150 mg PO q12h]
Info: for pts w/ ivacaftor-responsive CFTR gene mutations; give w/ fat-containing food

Renal dosing

CrCl >31: no adjustment; CrCl <31: not defined, caution advised
HD/PD: not defined, caution advised

Hepatic dosing

[adjust dose frequency]
Child-Pugh Class B: 150 mg qd; Child-Pugh Class C: 150 mg qd or less frequently

Recommended Peds Dosing

Dosage forms:  TAB: 150 mg; GRANULE: 25 mg per pkt, 50 mg per pkt, 75 mg per pkt

Cystic fibrosis

[4-5 mo, >5 kg]
Dose: 25 mg PO q12h; Info: for pts w/ ivacaftor-responsive CFTR gene mutations; give w/ fat-containing food
[6 mo-5 yo, 5-6.9 kg]
Dose: 25 mg PO q12h; Info: for pts w/ ivacaftor-responsive CFTR gene mutations; give w/ fat-containing food
[6 mo-5 yo, 7-13.9 kg]
Dose: 50 mg PO q12h; Info: for pts w/ ivacaftor-responsive CFTR gene mutations; give w/ fat-containing food
[6 mo-5 yo, >14 kg]
Dose: 75 mg PO q12h; Info: for pts w/ ivacaftor-responsive CFTR gene mutations; give w/ fat-containing food
[6 yo and older]
Dose: 150 mg PO q12h; Info: for pts w/ ivacaftor-responsive CFTR gene mutations; give w/ fat-containing food

Renal dosing

CrCl >31: no adjustment; CrCl <31: not defined, caution advised
HD/PD: not defined, caution advised

Hepatic dosing

[4-5 mo, >5 kg]
hepatic impairment: avoid use
[6 mo-5 yo, 5-6.9 kg]
Child-Pugh Class B: 25 mg qd; Child-Pugh Class C: 25 mg qd or less frequently
[6 mo-5 yo, 7-13.9 kg]
Child-Pugh Class B: 50 mg qd; Child-Pugh Class C: 50 mg qd or less frequently
[6 mo-5 yo, >14 kg]
Child-Pugh Class B: 75 mg qd; Child-Pugh Class C: 75 mg qd or less frequently
[6 yo and older]
Child-Pugh Class B: 150 mg qd; Child-Pugh Class C: 150 mg qd or less frequently

 

SRC: NLM .