Kaletra Dosage

Recommended Adult Dosing

HIV infection

[non-pregnant pts]

Dose: 400 mg/100 mg PO bid; Info: may give 800 mg/200 mg PO qd in pts w/ <3 lopinavir resistance-assoc. substitutions; incr. dose to 500 mg/125 mg tab PO bid or 520 mg/130 mg solution PO bid when used w/ efavirenz, fosamprenavir, nelfinavir, or nevirapine; do not cut/crush/chew tab; give oral solution w/ food

[pregnant pts]

Dose: 400 mg/100 mg tab PO bid; Info: for pts w/o lopinavir resistance-assoc. substitutions; incr. dose to 500 mg/125 mg tab PO bid when used w/ efavirenz, fosamprenavir, nelfinavir, or nevirapine; do not cut/crush/chew tab; avoid oral solution

HIV post-exposure prophylaxis

[400 mg/100 mg PO bid]

Info: part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Occupational and HIV Post-Exposure Prophylaxis, Nonoccupational tables; do not cut/crush/chew tab; give oral solution w/ food; avoid oral solution in pregnant pts

Renal dosing

renal impairment: no adjustment

HD: avoid use if qd regimen; no adjustment if bid regimen; no supplement after dialysis; PD: no adjustment; no supplement

Hepatic dosing

[not defined]

hepatic impairment: caution advised

Recommended Peds Dosing

Dosage forms:  TAB: 100 mg/25 mg, 200 mg/50 mg; SOL: 400 mg/100 mg per 5 mL

HIV infection

[oral solution, 14 days old-12 mo]

Dose: 16 mg/4 mg/kg/dose solution PO bid; Alt: 300 mg/75 mg/m^2/dose solution PO bid; Info: give w/ food

[tx-naïve pts, oral solution, 13 mo and older, <15 kg]

Dose: 12 mg/3 mg/kg/dose solution PO bid; Alt: 230 mg/57.5 mg/m^2/dose solution PO bid; Info: incr. dose to 300 mg/75 mg/m^2/dose solution PO bid when used w/ efavirenz, fosamprenavir, nelfinavir, or nevirapine; give w/ food

[tx-naïve pts, 13 mo and older, 15-40 kg]

Dose: 10 mg/2.5 mg/kg/dose PO bid; Alt: 230 mg/57.5 mg/m^2/dose PO bid; Info: incr. dose to 300 mg/75 mg/m^2/dose PO bid when used w/ efavirenz, fosamprenavir, nelfinavir, or nevirapine; do not cut/crush/chew tab; give oral solution w/ food; avoid oral solution in pregnant pts

[tx-experienced pts, oral solution, 13 mo and older, <15 kg]

Dose: 13 mg/3.25 mg/kg/dose solution PO bid; Max: 400 mg/100 mg bid; Alt: 300 mg/75 mg/m^2/dose solution PO bid; Info: incr. dose to 300 mg/75 mg/m^2/dose solution PO bid when used w/ efavirenz, fosamprenavir, nelfinavir, or nevirapine; give w/ food

[tx-experienced pts, 13 mo and older, 15-45 kg]

Dose: 11 mg/2.75 mg/kg/dose PO bid; Max: 400 mg/100 mg bid; Alt: 300 mg/75 mg/m^2/dose PO bid; Info: when used w/ efavirenz, fosamprenavir, nelfinavir, or nevirapine, incr. dose to 300 mg/75 mg/m^2/dose PO bid; do not cut/crush/chew tab; give oral solution w/ food; avoid oral solution in pregnant pts

[tx-experienced pts, 13 mo and older, >45 kg]

Dose: 400 mg/100 mg PO bid; Info: incr. dose to 500 mg/125 mg tab PO bid or 520 mg/130 mg solution PO bid when used w/ efavirenz, fosamprenavir, nelfinavir, or nevirapine; do not cut/crush/chew tab; give oral solution w/ food; avoid oral solution in pregnant pts

HIV post-exposure prophylaxis, nonoccupational

[oral solution, 14 days old-12 mo]

Dose: 16 mg/4 mg/kg/dose solution PO bid; Alt: 300 mg/75 mg/m^2/dose solution PO bid; Info: part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Nonoccupational table; give w/ food

[oral solution, 13 mo and older, <15 kg]

Dose: 12 mg/3 mg/kg/dose solution PO bid; Max: 400 mg/100 mg bid; Info: part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Nonoccupational table; give w/ food

[oral solution, 13 mo and older, 15-40 kg]

Dose: 10 mg/2.5 mg/kg/dose solution PO bid; Max: 400 mg/100 mg bid; Info: part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Nonoccupational table; give w/ food; avoid oral solution in pregnant pts

[oral solution, 13 mo and older, >40 kg]

Dose: 400 mg/100 mg solution PO bid; Info: part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Nonoccupational table; give w/ food; avoid oral solution in pregnant pts

[oral tab, 13 mo and older, 15-25 kg]

Dose: 200 mg/50 mg tab PO bid; Info: part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Nonoccupational table; do not cut/crush/chew tab

[oral tab, 13 mo and older, 25-35 kg]

Dose: 300 mg/75 mg tab PO bid; Info: part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Nonoccupational table; do not cut/crush/chew tab

[oral tab, 13 mo and older, >35 kg]

Dose: 400 mg/100 mg tab PO bid; Info: part of multi-drug regimen; refer to HIV Post-Exposure Prophylaxis, Nonoccupational table; do not cut/crush/chew tab

Renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: consider adult renal dosing for guidance

Hepatic dosing

[not defined]

hepatic impairment: caution advised