What is Jetrea?
Jetrea is a prescription medicine that is used to treat vitreomacular adhesion (VMA).
Ocriplasmin is a recombinant truncated form of human plasmin with a molecular weight of 27.2 kDa produced by recombinant DNA technology in a Pichia pastoris expression system.
JETREA is a sterile, clear and colorless solution with no preservatives in a single-use glass vial containing 0.375 mg ocriplasmin in 0.3 mL solution for intravitreal injection.
Each vial contains 0.375 mg ocriplasmin (active), 0.16 mg citric acid, 0.56 mg mannitol, 1.35 mg sodium chloride, sodium hydroxide and hydrochloric acid (for pH adjustment), and water for injection (q.s.). The pH of the solution is 3.1.
Before taking Jetrea, tell your doctor:
- If you are allergic to Jetrea; any part of this medicine; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
This medicine may interact with other drugs or health problems.
Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Jetrea with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.
What are some things I need to know or do while I take Jetrea?
- Tell all of your health care providers that you take Jetrea. This includes your doctors, nurses, pharmacists, and dentists.
- Use care when driving or doing other tasks that call for clear eyesight.
- Do not get this shot in the same eye more than 1 time. Talk with the doctor.
- Have your eye pressure and eyesight checked as you have been told by the doctor.
- Do not give to a child. Talk with your doctor.
- Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using Jetrea while you are pregnant.
- Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
How is Jetrea best taken?
Use Jetrea as ordered by your doctor. Read all information given to you. Follow all instructions closely.
- It is given as a shot into the eye.
What do I do if I miss a dose?
- Call your doctor to find out what to do.
What are the side effects of Jetrea that I need to call my doctor about immediately?
WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:
- Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
- Bleeding where the shot is given.
- Eye redness.
- Eye or eyelid swelling.
- If bright lights bother your eyes.
- Change in eyesight, eye pain, or very bad eye irritation.
What are some other side effects of Jetrea?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Seeing floaters.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-332-1088.
If overdose is suspected:
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How do I store and/or throw out Jetrea?
- If you need to store Jetrea at home, talk with your doctor, nurse, or pharmacist about how to store it.