Jentadueto Dosage

Recommended Adult Dosing

Dosage forms:  TAB: 2.5 mg/500 mg, 2.5 mg/850 mg, 2.5 mg/1000 mg

Diabetes mellitus, type 2

[conversion from linagliptin plus metformin]

Dose: 1 tab PO bid; Start: equivalent dose of each component in current regimen; Max: 5 mg/2000 mg/day; Info: give w/ meals; hold tx for surgery if restricting food/fluid; D/C for iodinated contrast study if eGFR 30-60, hepatic dz hx, alcoholism hx, heart failure hx, or receiving contrast intra-arterially; restart after 48h if stable renal fxn

[conversion from linagliptin]

Dose: 1 tab PO bid; Start: 2.5 mg/500 mg PO bid; Max: 5 mg/2000 mg/day; Info: give w/ meals; hold tx for surgery if restricting food/fluid; D/C for iodinated contrast study if eGFR 30-60, hepatic dz hx, alcoholism hx, heart failure hx, or receiving contrast intra-arterially; restart after 48h if stable renal fxn

[conversion from metformin]

Dose: 1 tab PO bid; Start: linagliptin 2.5 mg PO bid w/ current metformin dose PO bid; Max: 5 mg/2000 mg/day; Info: give w/ meals; hold tx for surgery if restricting food/fluid; D/C for iodinated contrast study if eGFR 30-60, hepatic dz hx, alcoholism hx, heart failure hx, or receiving contrast intra-arterially; restart after 48h if stable renal fxn

Renal dosing

eGFR 30-44: avoid tx initiation; eGFR <30: contraindicated; Info: weigh risk/benefit if eGFR 30-44 during tx

HD/PD: avoid use

Hepatic dosing

hepatic impairment: avoid use