Janumet Dosage

Generic name: metformin and sitagliptin
Brand names: JanumetJanumet XR
Drug class: Antidiabetic combinations

Medically reviewed by  A Ras MD.

 

Recommended Adult Dosing

Dosage forms:  TAB: 50 mg/500 mg, 50 mg/1000 mg

Diabetes mellitus, type 2

[conversion from sitagliptin plus metformin]
Dose: 1 tab PO bid; Start: equivalent dose of each component in current regimen; if on metformin 850 mg PO bid, start 50 mg/1000 mg PO bid; Max: 100 mg/2000 mg/day; Info: give w/ meals; do not cut/crush/chew tab; hold tx for surgery if restricting food/fluid; D/C for iodinated contrast study if eGFR 30-60, hepatic dz hx, alcoholism hx, heart failure hx, or receiving contrast intra-arterially; restart after 48h if stable renal fxn
[conversion from sitagliptin]
Dose: 1 tab PO bid; Start: 50 mg/500 mg PO bid; Max: 100 mg/2000 mg/day; Info: give w/ meals; do not cut/crush/chew tab; hold tx for surgery if restricting food/fluid; D/C for iodinated contrast study if eGFR 30-60, hepatic dz hx, alcoholism hx, heart failure hx, or receiving contrast intra-arterially; restart after 48h if stable renal fxn
[conversion from metformin]
Dose: 1 tab PO bid; Start: sitagliptin 50 mg PO bid plus current metformin dose PO bid; if on metformin 850 mg PO bid, start 50 mg/1000 mg PO bid; Max: 100 mg/2000 mg/day; Info: give w/ meals; do not cut/crush/chew tab; hold tx for surgery if restricting food/fluid; D/C for iodinated contrast study if eGFR 30-60, hepatic dz hx, alcoholism hx, heart failure hx, or receiving contrast intra-arterially; restart after 48h if stable renal fxn

Renal dosing

eGFR 30-45: avoid use; dose adjustment not possible w/ fixed-dose combo; eGFR <30: contraindicated
HD/PD: avoid use

Hepatic dosing

hepatic impairment: avoid use

 

SRC: NLM .