Jadenu Dosage

Generic name: deferasirox
Brand names: Jadenu, Jadenu Sprinkle
Drug class: Chelating agents

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  TAB: 90 mg, 180 mg, 360 mg

Iron overload, chronic transfusional

[14-21 mg/kg/dose PO qd]

Start: 14 mg/kg/dose PO qd; Max: 28 mg/kg/day; Info: adjust dose by 3.5-7 mg/kg/day q3-6mo based on serum ferritin trends (see pkg insert); hold tx if serum ferritin levels <500 mcg/L; decr. dose by 7 mg/kg/day if Cr >33% above baseline confirmed w/ 2 measurements w/in 1wk; give on empty stomach or w/ light meal; use minimum effective dose

Iron overload, chronic non-transfusion-dependent thalassemia-assoc.

[7-14 mg/kg/dose PO qd]

Start: 7 mg/kg/dose PO qd; Max: 14 mg/kg/day; Info: adjust dose based on serum ferritin trends and liver iron concentration (see pkg insert); hold tx if serum ferritin levels <300 mcg/L and/or liver iron concentration <3 mg Fe/g dw; decr. dose 50% or hold tx if already on 3.5 mg/kg/day if Cr >33% above baseline confirmed w/ 2 measurements w/in 1wk; give on empty stomach or w/ light meal; use minimum effective dose

Renal dosing

eGFR 40-60: decr. usual start dose by 50%; eGFR <40: contraindicated

HD/PD: not defined

Hepatic dosing

Child-Pugh Class B: decr. usual start dose by 50%; Child-Pugh Class C: avoid use

Recommended Peds Dosing

Dosage forms:  TAB: 90 mg, 180 mg, 360 mg

Iron overload, chronic transfusional

[2 yo and older]

Dose: 14-21 mg/kg/dose PO qd; Start: 14 mg/kg/dose PO qd; Max: 28 mg/kg/day; Info: adjust dose by 3.5-7 mg/kg/day q3-6mo based on serum ferritin trends (see pkg insert); hold tx if serum ferritin levels <500 mcg/L; decr. dose by 7 mg/kg/day if eGFR decr. >33% below baseline confirmed w/ 2 measurements w/in 1wk; hold tx for acute illness w/ volume depletion risk; give on empty stomach or w/ light meal; use minimum effective dose

Iron overload, chronic non-transfusion-dependent thalassemia-assoc.

[10 yo and older]

Dose: 7-14 mg/kg/dose PO qd; Start: 7 mg/kg/dose PO qd; Max: 14 mg/kg/day; Info: adjust dose based on serum ferritin trends and liver iron concentration (see pkg insert); hold tx if serum ferritin levels <300 mcg/L and/or liver iron concentration <3 mg Fe/g dw; decr. dose by 3.5 mg/kg/day if eGFR decr. >33% below baseline confirmed w/ 2 measurements w/in 1wk; consider holding tx for acute illness w/ volume depletion risk; give on empty stomach or w/ light meal; use minimum effective dose

Renal dosing

eGFR 40-60: decr. usual start dose by 50%; eGFR <40: contraindicated

HD/PD: not defined

Hepatic dosing

Child-Pugh Class B: decr. usual start dose by 50%; Child-Pugh Class C: avoid use

SRC: NLM .