Isturisa Dosage

Generic name: osilodrostat
Drug class: Adrenal corticosteroid inhibitors

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  TAB: 1 mg, 5 mg, 10 mg

Cushing disease

[2-7 mg PO bid]

Start: 2 mg PO bid, then may incr. dose by 2-4 mg/day no more frequently than q2wk; Max: 60 mg/day; Info: for pts ineligible for or failed curative pituitary surgery; adjust dose based on tx response and urinary free cortisol levels; in pts w/ elevated cortisol levels receiving 10 mg bid, may further incr. dose by 10 mg/day no more frequently than q2wk

Renal dosing

renal impairment: no adjustment; Info: reduced urine free cortisol excretion if mod-severe renal impairment; adjust dose based on urine free cortisol levels

HD/PD: not defined

Hepatic dosing

Child-Pugh Class B: start 1 mg bid; Child-Pugh Class C: start 1 mg qhs

SRC: NLM .