Invega Sustenna Dosage

Generic name: paliperidone (injection)
Drug class: Atypical antipsychotics

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  INJ (pre-filled syringe): 39 mg per 0.25 mL, 78 mg per 0.5 mL, 117 mg per 0.75 mL, 156 mg per mL, 234 mg per 1.5 mL

Schizophrenia

[39-234 mg IM qmo]

Start: 234 mg IM x1 on day 1, then 156 mg IM x1 on day 8, then 117 mg IM qmo; Max: 234 mg/mo; Info: may adjust dose qmo; see pkg insert for conversion and missed dose recommendations; periodically reassess need for tx

Schizoaffective disorder

[78-234 mg IM qmo]

Start: 234 mg IM x1 on day 1, then 156 mg IM x1 on day 8, then 78-234 mg IM qmo; Max: 234 mg/mo; Info: for monotherapy or adjunct to mood stabilizers and/or antidepressants; may adjust dose qmo; see pkg insert for conversion and missed dose recommendations; periodically reassess need for tx

Renal dosing

CrCl 50-79: start 156 mg IM x1 on day 1, then 117 mg IM x1 on day 8, then 78 mg IM qmo, then may increase to max 156 mg/mo; CrCl <50: avoid use

HD/PD: not defined

Hepatic dosing

Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined

SRC: NLM .