Inspra Dosage

Generic name: eplerenone
Drug classes: Aldosterone receptor antagonists, Potassium-sparing diuretics

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  TAB: 25 mg, 50 mg

Heart failure w/ reduced ejection fraction, post-MI

[50 mg PO qd]

Start: 25 mg PO qd, incr. to 50 mg PO qd after 4wk; Max: 50 mg/day; Info: see pkg insert for dose adjustments based on potassium levels

Hypertension

[50 mg PO qd-bid]

Start: 50 mg PO qd, may incr. to 50 mg PO bid after 4wk; Max: 100 mg/day

Renal dosing

[heart failure w/ reduced ejection fraction, post-MI]

eGFR 31-49: start 25 mg qod, may incr. to 25 mg qd after 4wk, max 25 mg/day; eGFR or CrCl <31: contraindicated

HD/PD: not defined

[HTN]

Cr >2 (males) or >1.8 (females), CrCl <50: contraindicated

HD/PD: not defined

Hepatic dosing

mild-mod impairment: no adjustment; severe impairment: not defined

SRC: NLM .