Imbruvica Dosage
Generic name: ibrutinib
Drug class: BTK inhibitors
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: CAP: 70 mg, 140 mg; TAB: 140 mg, 280 mg, 420 mg, 560 mg
Mantle cell lymphoma, relapsed or refractory
- [560 mg PO qd]
- Info: do not open cap; do not cut/crush/chew tab
CLL/SLL
- [420 mg PO qd]
- Info: use as monotherapy, w/ obinutuzumab, w/ rituximab, or part of multi-drug chemo regimen; do not open cap; do not cut/crush/chew tab
Waldenstrom macroglobulinemia
- [420 mg PO qd]
- Info: use as monotherapy or w/ rituximab; do not open cap; do not cut/crush/chew tab
Marginal zone lymphoma, relapsed or refractory
- [560 mg PO qd]
- Info: do not open cap; do not cut/crush/chew tab
Chronic GVHD, refractory
- [420 mg PO qd]
- Info: do not open cap; do not cut/crush/chew tab
Renal dosing
- CrCl >25: no adjustment; CrCl <25: not defined
- HD/PD: not defined
Hepatic dosing
- Child-Pugh Class A: 140 mg qd; Child-Pugh Class B: 70 mg qd; Child-Pugh Class C: avoid use
SRC: NLM .