Ilaris Dosage

Generic name: canakinumab
Drug class: Interleukin inhibitors

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  INJ: 150 mg per mL

Cryopyrin-assoc. periodic syndromes

[<41 kg]

Dose: 2 mg/kg/dose SC q8wk

[>41 kg]

Dose: 150 mg SC q8wk

TNF receptor-assoc. periodic syndrome

[<41 kg]

Dose: 2 mg/kg/dose SC q4wk; Info: may incr. to 4 mg/kg/dose SC q4wk if inadequate response

[>41 kg]

Dose: 150 mg SC q4wk; Info: may incr. to 300 mg SC q4wk if inadequate response

Hyperimmunoglobulin D syndrome/mevalonate kinase deficiency

[<41 kg]

Dose: 2 mg/kg/dose SC q4wk; Info: may incr. to 4 mg/kg/dose SC q4wk if inadequate response

[>41 kg]

Dose: 150 mg SC q4wk; Info: may incr. to 300 mg SC q4wk if inadequate response

Familial Mediterranean fever

[<41 kg]

Dose: 2 mg/kg/dose SC q4wk; Info: may incr. to 4 mg/kg/dose SC q4wk if inadequate response

[>41 kg]

Dose: 150 mg SC q4wk; Info: may incr. to 300 mg SC q4wk if inadequate response

Adult-onset Still dz

[4 mg/kg/dose SC q4wk]

Max: 300 mg/dose

Renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

Hepatic dosing

[not defined]

Recommended Peds Dosing

Dosage forms:  INJ: 150 mg per mL

Cryopyrin-assoc. periodic syndromes

[4 yo and older, 15-40 kg]

Dose: 2 mg/kg/dose SC q8wk; Info: may incr. to 3 mg/kg/dose SC q8wk if inadequate response

[4 yo and older, >41 kg]

Dose: 150 mg SC q8wk

TNF receptor-assoc. periodic syndrome

[<41 kg]

Dose: 2 mg/kg/dose SC q4wk; Info: may incr. to 4 mg/kg/dose SC q4wk if inadequate response

[>41 kg]

Dose: 150 mg SC q4wk; Info: may incr. to 300 mg SC q4wk if inadequate response

Hyperimmunoglobulin D syndrome/mevalonate kinase deficiency

[<41 kg]

Dose: 2 mg/kg/dose SC q4wk; Info: may incr. to 4 mg/kg/dose SC q4wk if inadequate response

[>41 kg]

Dose: 150 mg SC q4wk; Info: may incr. to 300 mg SC q4wk if inadequate response

Familial Mediterranean fever

[<41 kg]

Dose: 2 mg/kg/dose SC q4wk; Info: may incr. to 4 mg/kg/dose SC q4wk if inadequate response

[>41 kg]

Dose: 150 mg SC q4wk; Info: may incr. to 300 mg SC q4wk if inadequate response

Systemic juvenile idiopathic arthritis

[2 yo and older, >7.5 kg]

Dose: 4 mg/kg/dose SC q4wk; Max: 300 mg/dose

Renal dosing

[not defined]

renal impairment: not defined

HD/PD: not defined

Hepatic dosing

[not defined]

SRC: NLM .