Hyzaar Dosage

Generic name: hydrochlorothiazide and losartan
Drug class: Angiotensin II inhibitors with thiazides

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  TAB: 50 mg/12.5 mg, 100 mg/12.5 mg, 100 mg/25 mg

Hypertension

[1 tab PO qd]

Start: 50 mg/12.5 mg PO qd if on HCTZ 25 mg/day or losartan 50 mg/day or as initial tx for severe HTN; 100 mg/12.5 mg PO qd if on losartan 100 mg/day; may incr. to 100 mg/25 mg PO qd after 3wk if inadequate response; Max: 100 mg/25 mg/day

Stroke prevention

[1 tab PO qd]

Start: 50 mg/12.5 mg PO qd if on losartan 50 mg/day, may incr. to 100 mg/12.5 mg PO qd, then may incr. to 100 mg/25 mg PO qd if needed; Max: 100 mg/25 mg/day; Info: for pts w/ HTN and LVH; possibly ineffective in Black pts; not for initial tx

Renal dosing

CrCl >30: no adjustment; CrCl 10-30: not defined, caution advised; CrCl <10: avoid use; anuria: contraindicated

HD/PD: avoid use

Hepatic dosing

hepatic impairment: avoid use as initial tx; Info: lower losartan doses not possible w/ fixed-dose combo

SRC: NLM .