Hemlibra Dosage
Generic name: emicizumab
Drug class: Miscellaneous coagulation modifiers
Medically reviewed by A Ras MD.
Recommended Adult Dosing
Dosage forms: INJ (vial): 30 mg per mL, 60 mg per 0.4 mL, 105 mg per 0.7 mL, 150 mg per mL
Routine bleeding prophylaxis, hemophilia A
- [1.5 mg/kg/dose SC qwk]
- Start: 3 mg/kg/dose SC qwk x4wk; Alt: 3 mg/kg/dose SC q2wk; 6 mg/kg/dose SC q4wk; Info: D/C prophylactic use of bypassing agents 24h before 1st dose; may overlap w/ prophylactic use of factor VIII up to 1wk
Renal dosing
- [see below]
- CrCl >30: no adjustment; CrCl <30: not defined
- HD/PD: not defined
Hepatic dosing
- bilirubin 1-3x ULN and any AST: no adjustment; bilirubin >3x ULN: not defined
Recommended Peds Dosing
- Dosage forms: INJ (vial): 30 mg per mL, 60 mg per 0.4 mL, 105 mg per 0.7 mL, 150 mg per mL
Routine bleeding prophylaxis, hemophilia A
- [1.5 mg/kg/dose SC qwk]
- Start: 3 mg/kg/dose SC qwk x4wk; Alt: 3 mg/kg/dose SC q2wk; 6 mg/kg/dose SC q4wk; Info: D/C prophylactic use of bypassing agents 24h before 1st dose; may overlap w/ prophylactic use of factor VIII up to 1wk
Renal dosing
- CrCl >30: no adjustment; CrCl <30: not defined
- HD/PD: not defined
Hepatic dosing
- bilirubin 1-3x ULN and any AST: no adjustment; bilirubin >3x ULN: not defined
SRC: NLM .