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Gleevec Dosage

Generic name: Imatinib
Drug class: BCR-ABL tyrosine kinase inhibitors

Medically reviewed by  A Ras MD.

 

Recommended Adult Dosing

Dosage forms:  TAB: 100 mg, 400 mg

Ph-positive CML

[chronic phase, newly diagnosed]
Dose: 400 mg PO qd; Info: may incr. dose to 600 mg PO qd if dz progression, hematologic response not achieved after at least 3mo tx, cytogenetic response not achieved after 6-12mo tx, or loss of hematologic or cytogenetic response; give w/ meal
[chronic phase, resistant or intolerant dz]
Dose: 400 mg PO qd; Info: may incr. dose to 600 mg PO qd if dz progression, hematologic response not achieved after at least 3mo tx, cytogenetic response not achieved after 6-12mo tx, or loss of hematologic or cytogenetic response; give w/ meal
[accelerated phase or blast phase, resistant or intolerant dz]
Dose: 600 mg PO qd; Info: may incr. dose to 400 mg PO bid if dz progression, hematologic response not achieved after at least 3mo tx, cytogenetic response not achieved after 6-12mo tx, or loss of hematologic or cytogenetic response; give w/ meal

Ph-positive ALL, relapsed or refractory

[600 mg PO qd]
Info: give w/ meal

Myelodysplastic/myeloproliferative dz

[400 mg PO qd]
Info: for pts w/ PDGFR gene re-arrangements; give w/ meal

Aggressive systemic mastocytosis

[400 mg PO qd]
Info: for pts w/o D816V c-Kit mutation or unknown c-Kit mutation status; start 100 mg PO qd if eosinophilia-assoc. dz; give w/ meal

Hypereosinophilic syndrome and/or CEL

[400 mg PO qd]
Info: start 100 mg PO qd in pts w/ FIP1L1-PDGFR alfa fusion kinase; give w/ meal

Dermatofibrosarcoma protuberans, advanced

[400 mg PO bid]
Info: give w/ meal

Kit-positive gastrointestinal stromal tumor

[adjuvant tx]
Dose: 400 mg PO qd x3y; Info: give w/ meal
[unresectable or metastatic dz]
Dose: 400 mg PO qd; Max: 400 mg PO bid; Info: give w/ meal

Renal dosing

[adjust dose amount]
CrCl 40-59: max 600 mg/day; CrCl 20-39: decr. usual start dose by 50%, max 400 mg/day; CrCl <20: decr. usual dose, amount not defined
HD/PD: not defined

Hepatic dosing

[adjust dose amount]
severe impairment: decr. dose 25%

Recommended Peds Dosing

Dosage forms:  TAB: 100 mg, 400 mg

Chronic phase Ph-positive CML, newly diagnosed

[1 yo and older]
Dose: 340 mg/m^2/day PO divided qd-bid; Max: 600 mg/day; Info: give w/ meal

Ph-positive ALL, newly diagnosed

[1 yo and older]
Dose: 340 mg/m^2/dose PO qd; Max: 600 mg/day; Info: part of multi-drug chemo regimen; give w/ meal

Renal dosing

[not defined]
renal impairment: consider adult renal dosing for guidance
HD/PD: not defined

Hepatic dosing

[not defined]
hepatic impairment: consider adult hepatic dosing for guidance

SRC: NLM .

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