Ganciclovir Dosage

Generic name: ganciclovir (injection)
Brand name: Cytovene
Dosage forms: intravenous powder for injection (500 mg); intravenous solution (2 mg/mL-NaCl 0.8%; 50 mg/mL)
Drug class: Purine nucleosides

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  INJ

CMV prophylaxis, solid organ transplant

[induction tx]

Dose: 5 mg/kg/dose IV q12h x7-14 days

[maintenance tx]

Dose: 5 mg/kg/dose IV q24h; Alt: 6 mg/kg IV 5x/wk

CMV retinitis, immunocompromised pts

[induction tx]

Dose: 5 mg/kg/dose IV q12h x14-21 days; Info: not 1st-line agent

[maintenance tx]

Dose: 5 mg/kg/dose IV q24h; Alt: 6 mg/kg IV 5x/wk; Info: not 1st-line agent

Renal dosing

[induction tx]

CrCl 50-69: 2.5 mg/kg/dose q12h; CrCl 25-49: 2.5 mg/kg/dose q24h; CrCl 10-24: 1.25 mg/kg/dose q24h; CrCl <10: 1.25 mg/kg/dose 3x/wk

HD: max 1.25 mg/kg/dose 3x/wk after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: 1.25 mg/kg/dose 3x/wk; supplement not defined

[maintenance tx]

CrCl 50-69: 2.5 mg/kg/dose q24h; CrCl 25-49: 1.25 mg/kg/dose q24h; CrCl 10-24: 0.625 mg/kg/dose q24h; CrCl <10: 0.625 mg/kg/dose 3x/wk

HD: max 0.625 mg/kg/dose 3x/wk after dialysis; consider supplement if next maint. dose not due right after dialysis; PD: 0.625 mg/kg/dose 3x/wk; supplement not defined

Hepatic dosing

[not defined]

SRC: NLM .