Fycompa Dosage

Generic name: perampanel
Drug class: AMPA receptor antagonists

Medically reviewed by  A Ras MD.

 

Recommended Adult Dosing

Dosage forms:  TAB: 2 mg, 4 mg, 6 mg, 8 mg, 10 mg, 12 mg; SUSP: 0.5 mg per mL

Partial seizures

[monotherapy]
Dose: 8-12 mg PO qhs; Start: 2 mg PO qhs, then incr. by 2 mg/day no more frequently than qwk; Max: 12 mg/day; Info: in elderly pts, incr. dose no more frequently than q2wk; taper dose gradually to D/C
[enzyme-inducing AED adjunct]
Dose: 8-12 mg PO qhs; Start: 4 mg PO qhs, then incr. by 2 mg/day no more frequently than qwk; Max: 12 mg/day; Info: in elderly pts, incr. dose no more frequently than q2wk; enzyme-inducing AEDs incl. carbamazepine, phenytoin, phenobarbital, primidone; taper dose gradually to D/C
[non-inducing AED adjunct]
Dose: 8-12 mg PO qhs; Start: 2 mg PO qhs, then incr. by 2 mg/day no more frequently than qwk; Max: 12 mg/day; Info: in elderly pts, incr. dose no more frequently than q2wk; taper dose gradually to D/C

Seizures, primary generalized tonic clonic

[enzyme-inducing AED adjunct]
Dose: 8-12 mg PO qhs; Start: 4 mg PO qhs, then incr. by 2 mg/day no more frequently than qwk; Max: 12 mg/day; Info: in elderly pts, incr. dose no more frequently than q2wk; enzyme-inducing AEDs incl. carbamazepine, phenytoin, phenobarbital, primidone; taper dose gradually to D/C
[non-inducing AED adjunct]
Dose: 8-12 mg PO qhs; Start: 2 mg PO qhs, then incr. by 2 mg/day no more frequently than qwk; Max: 12 mg/day; Info: in elderly pts, incr. dose no more frequently than q2wk; taper dose gradually to D/C

Renal dosing

moderate impairment: caution advised, consider titrating slowly; severe impairment: avoid use
HD/PD: not defined

Hepatic dosing

[adjust dose amount, frequency]
Child-Pugh Class A: start 2 mg qhs, then incr. by 2 mg/day no more frequently than q2wk, max 6 mg/day; Child-Pugh Class B: start 2 mg qhs, then incr. by 2 mg/day no more frequently than q2wk, max 4 mg/day; Child-Pugh Class C: avoid use

Recommended Peds Dosing

Dosage forms:  TAB: 2 mg, 4 mg, 6 mg, 8 mg, 10 mg, 12 mg; SUSP: 0.5 mg per mL

Partial seizures

[monotherapy, 4 yo and older]
Dose: 8-12 mg PO qhs; Start: 2 mg PO qhs, then incr. by 2 mg/day no more frequently than qwk; Max: 12 mg/day; Info: taper dose gradually to D/C
[enzyme-inducing AED adjunct, 4 yo and older]
Dose: 8-12 mg PO qhs; Start: 4 mg PO qhs, then incr. by 2 mg/day no more frequently than qwk; Max: 12 mg/day; Info: enzyme-inducing AEDs incl. carbamazepine, phenytoin, phenobarbital, primidone; taper dose gradually to D/C
[non-inducing AED adjunct, 4 yo and older]
Dose: 8-12 mg PO qhs; Start: 2 mg PO qhs, then incr. by 2 mg/day no more frequently than qwk; Max: 12 mg/day; Info: taper dose gradually to D/C

Seizures, primary generalized tonic clonic

[enzyme-inducing AED adjunct, 12 yo and older]
Dose: 8-12 mg PO qhs; Start: 4 mg PO qhs, then incr. by 2 mg/day no more frequently than qwk; Max: 12 mg/day; Info: enzyme-inducing AEDs incl. carbamazepine, phenytoin, phenobarbital, primidone; taper dose gradually to D/C
[non-inducing AED adjunct, 12 yo and older]
Dose: 8-12 mg PO qhs; Start: 2 mg PO qhs, then incr. by 2 mg/day no more frequently than qwk; Max: 12 mg/day; Info: taper dose gradually to D/C

Renal dosing

moderate impairment: caution advised, consider titrating slowly; severe impairment: avoid use
HD/PD: not defined

Hepatic dosing

[adjust dose amount, frequency]
Child-Pugh Class A: start 2 mg qhs, then incr. by 2 mg/day no more frequently than q2wk, max 6 mg/day; Child-Pugh Class B: start 2 mg qhs, then incr. by 2 mg/day no more frequently than q2wk, max 4 mg/day; Child-Pugh Class C: avoid use

 

SRC: NLM .