Fosaprepitant Teva Dosage

Generic name: fosaprepitant
Brand name: Emend for Injection
Drug class: NK1 receptor antagonists

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  INJ

Nausea/vomiting prevention, chemo-related

[150 mg IV x1 on day 1]
Start: 30min before moderately or highly emetogenic chemo on day 1; Info: give w/ corticosteroid and 5-HT3 antagonist

Renal dosing

renal impairment: no adjustment
HD: no adjustment; no supplement; PD: not defined

Hepatic dosing

Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined

Recommended Peds Dosing

Dosage forms:  INJ

Special Note

[dosing clarification]
Info: for PO aprepitant dosing see aprepitant or Emend

Nausea/vomiting prevention, chemo-related

[1-day regimen, 6 mo-1 yo, >6 kg]
Dose: 5 mg/kg/dose IV x1 on day 1; Start: 30min before moderately or highly emetogenic chemo on day 1; Max: 150 mg/dose; Info: give w/ 5-HT3 antagonist and w/ or w/o corticosteroid
[1-day regimen, 2-11 yo]
Dose: 4 mg/kg/dose IV x1 on day 1; Start: 30min before moderately or highly emetogenic chemo on day 1; Max: 150 mg/dose; Info: give w/ 5-HT3 antagonist and w/ or w/o corticosteroid
[1-day regimen, 12-17 yo]
Dose: 150 mg IV x1 on day 1; Start: 30min before moderately or highly emetogenic chemo on day 1; Info: give w/ 5-HT3 antagonist and w/ or w/o corticosteroid
[3-day regimen, 6 mo-11 yo, >6 kg]
Dose: 3 mg/kg/dose IV x1 on day 1, then 2 mg/kg/dose IV qd on days 2-3; Start: 30min before moderately or highly emetogenic chemo on day 1; Max: 115 mg on day 1, 80 mg/day on days 2-3; Alt: 3 mg/kg/dose IV x1 on day 1, then oral aprepitant 2 mg/kg/dose PO qd on days 2-3; Info: give w/ 5-HT3 antagonist and w/ or w/o corticosteroid
[3-day regimen, 12-17 yo]
Dose: 115 mg IV x1 on day 1, then 80 mg IV qd on days 2-3; Start: 30min before moderately or highly emetogenic chemo on day 1; Alt: 115 mg IV x1 on day 1, then oral aprepitant 80 mg PO qd on days 2-3; Info: give w/ 5-HT3 antagonist and w/ or w/o corticosteroid

Renal dosing

renal impairment: no adjustment
HD: no adjustment; no supplement; PD: not defined

Hepatic dosing

Child-Pugh Class A or B: no adjustment; Child-Pugh Class C: not defined

 

SRC: NLM .