Fluorouracil Dosage

Generic name: fluorouracil (injection)
Dosage form: intravenous solution (50 mg/mL)
Drug class: Antimetabolites

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  INJ

Breast CA

[500 mg/m^2/dose IV x1 on days 1, 8 of 28-day cycle]

Alt: 600 mg/m^2/dose IV x1 on days 1, 8 of 28-day cycle; Info: give x6 cycles; part of multi-drug chemo regimen

Colorectal CA

[bolus regimen]

Dose: 500 mg/m^2/dose IV x1 on days 1, 8, 15, 22, 29, 36 of 56-day cycle; Info: give x4 cycles; use w/ (levo)leucovorin

[infusional regimen]

Dose: 400 mg/m^2/dose IV x1 on day 1, then 1200-1500 mg/m^2/24h IV infusion on days 1, 2 of 14-day cycle; Info: use w/ (levo)leucovorin w/ or w/o irinotecan or oxaliplatin

Gastric CA

[resectable dz]

Dose: 200 mg/m^2/24h IV infusion on days 1-21 of 21-day cycle; Alt: 800 mg/m^2/24h IV infusion on days 1-5 of 28-day cycle; Info: give x3 cycles preop, then x3 cycles postop; use w/ cisplatin or part of multi-drug chemo regimen

[advanced dz]

Dose: 750-1000 mg/m^2/24h IV infusion on days 1-4 of 28-day cycle; Info: use w/ cisplatin

Pancreatic CA

[400 mg/m^2/dose IV x1 on day 1, then 1200 mg/m^2/24h IV infusion on days 1, 2 of 14-day cycle]

Info: give x12 cycles; part of multi-drug chemo regimen

Renal dosing

renal impairment: no adjustment

HD: decr. usual dose by up to 50%, on dialysis days admin. after dialysis; no supplement; PD: not defined

Hepatic dosing

[not defined]

hepatic impairment: caution advised

SRC: NLM .