Firdapse Dosage

Generic name: amifampridine
Drug class: Cholinergic muscle stimulants

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  TAB: 10 mg

Restricted Distribution in US

Lambert-Eaton myasthenic syndrome

[15-80 mg/day PO divided tid-qid]

Start: 15-30 mg/day PO divided tid-qid, may incr. by 5 mg/day q3-4 days; Max: 20 mg/dose, 80 mg/day; Info: start 15 mg/day PO divided tid in poor N-acetyltransferase 2 (NAT2) metabolizers

Renal dosing

[adjust dose amount, frequency]

CrCl 15-90: start 15 mg/day divided tid; CrCl <15: not defined

HD/PD: not defined

Hepatic dosing

[adjust dose amount, frequency]

hepatic impairment: start 15 mg/day divided tid

SRC: NLM .