Ezetimibe and Simvastatin Dosage

Generic name: ezetimibe and simvastatin
Brand name: Vytorin
Drug class: Antihyperlipidemic combinations

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  TAB: 10 mg/10 mg, 10 mg/20 mg, 10 mg/40 mg, 10 mg/80 mg

Hypercholesterolemia

[1 tab PO qpm]

Start: 10 mg/10 mg-10 mg/20 mg PO qpm, may adjust dose q2wk; Max: 10 mg/40 mg/day; Info: may start 10 mg/40 mg PO qpm in pts w/ >55% LDL reduction goal; may convert from simvastatin monotherapy w/ same simvastatin dose

Mixed dyslipidemia

[1 tab PO qpm]

Start: 10 mg/10 mg-10 mg/20 mg PO qpm, may adjust dose q2wk; Max: 10 mg/40 mg/day; Info: may start 10 mg/40 mg PO qpm in pts w/ >55% LDL reduction goal; may convert from simvastatin monotherapy w/ same simvastatin dose

Homozygous familial hypercholesterolemia

[1 tab PO qpm]

Start: 10 mg/40 mg PO qpm; Max: 10 mg/40 mg/day; Info: may convert from simvastatin monotherapy w/ same simvastatin dose

Renal dosing

[adjust dose amount]

CrCl <60: 10 mg/20 mg qpm

HD/PD: not defined

Hepatic dosing

Child-Pugh Class B or C: avoid use; active hepatic dz/persistent elevated LFTs: contraindicated

Recommended Peds Dosing

Dosage forms:  TAB: 10 mg/10 mg, 10 mg/20 mg, 10 mg/40 mg

Heterozygous familial hypercholesterolemia

[10-17 yo, males and postmenarchal females]

Dose: 1 tab PO qpm; Start: 10 mg/10 mg PO qpm; Max: 10 mg/40 mg/day; Info: may convert from simvastatin monotherapy w/ same simvastatin dose

Renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: not defined

Hepatic dosing

Child-Pugh Class B or C: avoid use; active hepatic dz/persistent elevated LFTs: contraindicated

SRC: NLM .