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Exjade Dosage

Generic name: deferasirox
Drug class: Chelating agents

Medically reviewed by  A Ras MD.

 

Recommended Adult Dosing

Dosage forms:  DISPERSE TAB: 125 mg, 250 mg, 500 mg

Iron overload, chronic transfusional

[20-30 mg/kg/dose PO qd]
Start: 20 mg/kg/dose PO qd; Max: 40 mg/kg/day; Info: adjust dose by 5-10 mg/kg/day q3-6mo based on serum ferritin trends (see pkg insert); hold tx if serum ferritin levels <500 mcg/L; decr. dose by 10 mg/kg/day if Cr >33% above baseline confirmed w/ 2 measurements w/in 1wk; give 30min before meals; use minimum effective dose

Iron overload, chronic non-transfusion-dependent thalassemia-assoc.

[10-20 mg/kg/dose PO qd]
Start: 10 mg/kg/dose PO qd; Max: 20 mg/kg/day; Info: adjust dose based on serum ferritin trends and liver iron concentration (see pkg insert); hold tx if serum ferritin levels <300 mcg/L and/or liver iron concentration <3 mg Fe/g dw; decr. dose 50% or hold tx if already on 5 mg/kg/day if Cr >33% above baseline confirmed w/ 2 measurements w/in 1wk; give 30min before meals; use minimum effective dose

Renal dosing

eGFR 40-60: decr. usual start dose by 50%; eGFR <40: contraindicated
HD/PD: not defined

Hepatic dosing

Child-Pugh Class B: decr. usual start dose by 50%; Child-Pugh Class C: avoid use

Recommended Peds Dosing

Dosage forms:  DISPERSE TAB: 125 mg, 250 mg, 500 mg

Iron overload, chronic transfusional

[2 yo and older]
Dose: 20-30 mg/kg/dose PO qd; Start: 20 mg/kg/dose PO qd; Max: 40 mg/kg/day; Info: adjust dose by 5-10 mg/kg/day q3-6mo based on serum ferritin trends (see pkg insert); hold tx if serum ferritin levels <500 mcg/L; decr. dose by 10 mg/kg/day if eGFR decr. >33% below baseline confirmed w/ 2 measurements w/in 1wk; hold tx for acute illness w/ volume depletion risk; give 30min before meals; use minimum effective dose

Iron overload, chronic non-transfusion-dependent thalassemia-assoc.

[10 yo and older]
Dose: 10-20 mg/kg/dose PO qd; Start: 10 mg/kg/dose PO qd; Max: 20 mg/kg/day; Info: adjust dose based on serum ferritin trends and liver iron concentration (see pkg insert); hold tx if serum ferritin levels <300 mcg/L and/or liver iron concentration <3 mg Fe/g dw; decr. dose 50% or hold tx if already on 5 mg/kg/day if eGFR decr. >33% below baseline confirmed w/ 2 measurements w/in 1wk; consider holding tx for acute illness w/ volume depletion risk; give 30min before meals; use minimum effective dose

Renal dosing

eGFR 40-60: decr. usual start dose by 50%; eGFR <40: contraindicated
HD/PD: not defined

Hepatic dosing

Child-Pugh Class B: decr. usual start dose by 50%; Child-Pugh Class C: avoid use

SRC: NLM .

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