Evomela Dosage

Generic name: melphalan (intravenous route)
Drug class: Alkylating agents

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  INJ

Multiple myeloma, autologous HSCT conditioning tx

[100 mg/m^2/dose IV q24h on days -3, -2]

Info: use adjusted IBW for dose calculations if wt >130% of IBW

Multiple myeloma, palliative tx

[16 mg/m^2/dose IV x1 on day 1 of 28-day cycle, starting cycle 5]

Start: 16 mg/m^2/dose IV x1 on day 1 of 14-day cycle x4 cycles

Renal dosing

[HSCT conditioning tx]

renal impairment: no adjustment

HD/PD: not defined

[palliative tx]

CrCl 10-50: decr. usual dose by 25%; CrCl <10: decr. usual dose by 50%

HD: decr. usual dose by 50%, on dialysis days admin. after dialysis; no supplement; PD: decr. usual dose by 50%; no supplement

Hepatic dosing

[not defined]

SRC: NLM .