Ethionamide Dosage

Generic name: ethionamide
Brand names: Trecator, Trecator-SC
Dosage form: oral tablet (250 mg)
Drug class: Nicotinic acid derivatives

Medically reviewed by  A Ras MD.

Recommended Adult Dosing

Dosage forms:  TAB: 250 mg

Tuberculosis, active

[15-20 mg/kg/day PO divided qd-bid]

Start: 250 mg PO qd x1-2 days, then 250 mg bid x1-2 days; Max: 1000 mg/day; Info: part of multi-drug regimen; not 1st-line agent; give w/ food

Renal dosing

[adjust dose amount, frequency]

CrCl <30: 250-500 mg qd

HD: 250-500 mg qd, on dialysis days admin. after dialysis; no supplement; PD: not defined

Hepatic dosing

severe impairment: contraindicated

Recommended Peds Dosing

Dosage forms:  TAB: 250 mg

Tuberculosis, active

[2-14 yo]

Dose: 15-20 mg/kg/day PO divided qd-bid; Start: 250 mg PO qd x1-2 days, then 250 mg bid x1-2 days; Max: 750 mg/day; Info: part of multi-drug regimen; not 1st-line agent; give w/ food

[15 yo and older]

Dose: 15-20 mg/kg/day PO divided qd-bid; Start: 250 mg PO qd x1-2 days, then 250 mg bid x1-2 days; Max: 750 mg/day; Info: part of multi-drug regimen; not 1st-line agent; give w/ food

Renal dosing

[not defined]

renal impairment: consider adult renal dosing for guidance

HD/PD: consider adult renal dosing for guidance

Hepatic dosing

[see Adult Dosing]

severe impairment: contraindicated

SRC: NLM .